Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines

Master Thesis

2011

Permanent link to this Item
http://hdl.handle.net/11427/12240
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thesis_sci_2011_pineo_c.pdf (4.81 MB)
Authors
Pineo, Catherine
Supervisors
Rybicki, Ed
Hitzeroth, Inga
Journal Title
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Volume Title
Publisher
Publisher

University of Cape Town

Department
Department of Molecular and Cell Biology
Faculty
Faculty of Science
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Abstract
Cervical cancer is primarily caused by infection with Human papillomavirus (HPV) and is a global concern, particularly in developing countries which contain ~80% of the cervical cancer burden. Current HPV L1 major capsid protein virus-like particle (VLP)-based vaccines are effective in the type-specific prevention of infection and associated disease. However, the high cost of the vaccines has limited their widespread application, and cytological screening programmes are still required to detect malignant lesions associated with the non-vaccine types, particularly in HIV-infected populations.
Description

Includes abstract.


Includes bibliographical references (leaves 153-175).

Keywords
Cell Biology

Reference:

Pineo, C. 2011. Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines. University of Cape Town.

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