The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer

 

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dc.contributor.advisor Prince, Sharon en_ZA
dc.contributor.author Davis, Emily en_ZA
dc.date.accessioned 2015-01-10T06:48:15Z
dc.date.available 2015-01-10T06:48:15Z
dc.date.issued 2009 en_ZA
dc.identifier.citation Davis, E. 2009. The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/11890
dc.description Includes abstract. en_ZA
dc.description Includes bibliographical references (leaves 102-131). en_ZA
dc.description.abstract T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Human Biology en_ZA
dc.title The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Human Biology en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Davis, E. (2009). <i>The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology. Retrieved from http://hdl.handle.net/11427/11890 en_ZA
dc.identifier.chicagocitation Davis, Emily. <i>"The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2009. http://hdl.handle.net/11427/11890 en_ZA
dc.identifier.vancouvercitation Davis E. The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Human Biology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11890 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Davis, Emily AB - T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer TI - The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer UR - http://hdl.handle.net/11427/11890 ER - en_ZA


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