Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients

 

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dc.contributor.advisor Dandara, Collet en_ZA
dc.contributor.author Swart, Marelize en_ZA
dc.date.accessioned 2015-01-09T08:56:56Z
dc.date.available 2015-01-09T08:56:56Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Swart, M. 2011. Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/11835
dc.description Includes abstract. en_ZA
dc.description Includes bibliographical references (leaves 82-96). en_ZA
dc.description.abstract Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute to differences in EFV plasma concentrations which affect the levels of viral suppression as well as development of side effects in patients. The aim of this project was to evaluate the effects of the different genetic polymorphisms on EFV plasma concentration levels in HIV/AIDS patients receiving first-line antiretroviral treatment (ART) containing EFV. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Swart, M. (2011). <i>Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/11835 en_ZA
dc.identifier.chicagocitation Swart, Marelize. <i>"Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2011. http://hdl.handle.net/11427/11835 en_ZA
dc.identifier.vancouvercitation Swart M. Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11835 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Swart, Marelize AB - Efavirenz (EFV) is used in first-line antiretroviral (ARV) therapy of HIV-infected patients, and is principally metabolised by CYP1A2, CYP2A6, CYP2B6, CYP3A4/5 and the drug transporter ABCB1. Genetic variability in the above genes may contribute to differences in EFV plasma concentrations which affect the levels of viral suppression as well as development of side effects in patients. The aim of this project was to evaluate the effects of the different genetic polymorphisms on EFV plasma concentration levels in HIV/AIDS patients receiving first-line antiretroviral treatment (ART) containing EFV. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients TI - Pharmacogenetics of Efavirenz response in Bantu-speaking South African HIV/AIDS patients UR - http://hdl.handle.net/11427/11835 ER - en_ZA


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