HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy

 

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dc.contributor.advisor Heckmann, Jeannine M en_ZA
dc.contributor.advisor Dandara, Collet en_ZA
dc.contributor.advisor Wilkinson, Robert J en_ZA
dc.contributor.author Van der Watt, Johan J en_ZA
dc.date.accessioned 2015-01-06T18:54:59Z
dc.date.available 2015-01-06T18:54:59Z
dc.date.issued 2013 en_ZA
dc.identifier.citation Van der Watt, J. 2013. HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/11621
dc.description Includes abstract. en_ZA
dc.description Thesis (Ph.D. (Medicine))--University of Cape Town, 2013. en_ZA
dc.description.abstract Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic neuropathy (ATN). The purpose of this research was to investigate the characteristics of HIV-associated DSP over the first 24 weeks of starting cART in an African community-based cohort. Apart from studying the longitudinal association of candidate risk factors based on previous reports, we focused on two additional aspects. Firstly, the Nacetyltransferase 2 (NAT2) genotype, which determines an individual's acetylation status, influences the risk for isoniazid (INH)-associated neuropathy. en_ZA
dc.language.iso eng en_ZA
dc.title HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Van der Watt, J. J. (2013). <i>HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Medicine. Retrieved from http://hdl.handle.net/11427/11621 en_ZA
dc.identifier.chicagocitation Van der Watt, Johan J. <i>"HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013. http://hdl.handle.net/11427/11621 en_ZA
dc.identifier.vancouvercitation Van der Watt JJ. HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/11621 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Van der Watt, Johan J AB - Distal sensory polyneuropathy (DSP) amongst human immunodeficiency virus (HIV)-infected patients is frequently a painful and disabling condition. HIV-associated DSP is either a consequence of HIV (HIV-DSP) or antiretroviral-induced toxic neuropathy (ATN). The purpose of this research was to investigate the characteristics of HIV-associated DSP over the first 24 weeks of starting cART in an African community-based cohort. Apart from studying the longitudinal association of candidate risk factors based on previous reports, we focused on two additional aspects. Firstly, the Nacetyltransferase 2 (NAT2) genotype, which determines an individual's acetylation status, influences the risk for isoniazid (INH)-associated neuropathy. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy TI - HIV-associated sensory neuropathy in an African cohort a longitudinal study of risk factors predisposing to antiretroviral induced painful neuropathy UR - http://hdl.handle.net/11427/11621 ER - en_ZA


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