Extensively drug resistant tuberculosis in South Africa

 

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dc.contributor.advisor Dheda, Keertan en_ZA
dc.contributor.author Shean, Karen Penelope en_ZA
dc.date.accessioned 2015-01-06T18:54:54Z
dc.date.available 2015-01-06T18:54:54Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Shean, K. 2011. Extensively drug resistant tuberculosis in South Africa. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/11620
dc.description Includes abstract. en_ZA
dc.description Includes bibliographical references (leaves 161-168). en_ZA
dc.description.abstract There are few data for treatment-related outcomes in patients with XDR tuberculosis in settings with high HIV prevalence. We reviewed the case records of 227 consecutively diagnosed South African patients with XDR-TB between 2002 and 2008, and analysed the records of another 115 patients, retrospectively, for adverse drug reactions (ADRs). It was found that a significant proportion of XDR-TB patients are HIV unrelated, and prognosis, regardless of HIV status, poor. Nevertheless, survival in HIV infected patients is better than previously reported, and treatment with HAART improves outcomes. The frequency of ADR’s with XDR-TB treatment regimens is high, often severe, and negatively impacts on culture conversion outcomes. These data have implications for the formulation of recommendations for control programmes in resource-poor settings. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title Extensively drug resistant tuberculosis in South Africa en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image


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