Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species

 

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dc.contributor.advisor Sewell, Trevor en_ZA
dc.contributor.author Kimani, Serah en_ZA
dc.date.accessioned 2015-01-01T12:38:51Z
dc.date.available 2015-01-01T12:38:51Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Kimani, S. 2011. Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/10837
dc.description.abstract To investigate the structural determinants of NitN specificity on short aliphatic amide substrates by analyzing binding and interactions of these molecules with the NitN binding pocket. To probe the catalytic role of the two active site glutamate residues (Glu61 and Glu139) using NitN as a model enzyme. To monitor the activity, interactions and reactivity of the WT NitN and the Glu61 and Glu139 NitN mutants with ACR. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Cell Biology en_ZA
dc.title Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species en_ZA
dc.type Doctoral Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Molecular and Cell Biology en_ZA
dc.type.qualificationlevel Doctoral
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Kimani, S. (2011). <i>Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/10837 en_ZA
dc.identifier.chicagocitation Kimani, Serah. <i>"Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2011. http://hdl.handle.net/11427/10837 en_ZA
dc.identifier.vancouvercitation Kimani S. Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10837 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Kimani, Serah AB - To investigate the structural determinants of NitN specificity on short aliphatic amide substrates by analyzing binding and interactions of these molecules with the NitN binding pocket. To probe the catalytic role of the two active site glutamate residues (Glu61 and Glu139) using NitN as a model enzyme. To monitor the activity, interactions and reactivity of the WT NitN and the Glu61 and Glu139 NitN mutants with ACR. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species TI - Catalysis, substrate binding and specificity in the amidase from Nesterenkonia species UR - http://hdl.handle.net/11427/10837 ER - en_ZA


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