Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves

 

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dc.contributor.advisor Little, Francesca en_ZA
dc.contributor.advisor Barnes, Karen en_ZA
dc.contributor.author Mauff, Katya en_ZA
dc.date.accessioned 2014-12-31T19:46:06Z
dc.date.available 2014-12-31T19:46:06Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Mauff, K. 2011. Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/10719
dc.description.abstract This thesis discusses the techniques involved in the fitting of nonlinear mixed effect (NLME) models. In particular, it looks at the application of these techniques to the analysis of concentration-time data for the aforementioned antimalarial compounds, and details the necessary extensions to the basic modeling process that were required in order to accommodate multiple responses and multiple observation phases (pregnant and postpartum). en_ZA
dc.language.iso eng en_ZA
dc.subject.other Statistical Science en_ZA
dc.title Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Science en_ZA
dc.publisher.department Department of Statistical Sciences en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Mauff, K. (2011). <i>Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Statistical Sciences. Retrieved from http://hdl.handle.net/11427/10719 en_ZA
dc.identifier.chicagocitation Mauff, Katya. <i>"Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Statistical Sciences, 2011. http://hdl.handle.net/11427/10719 en_ZA
dc.identifier.vancouvercitation Mauff K. Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Statistical Sciences, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10719 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mauff, Katya AB - This thesis discusses the techniques involved in the fitting of nonlinear mixed effect (NLME) models. In particular, it looks at the application of these techniques to the analysis of concentration-time data for the aforementioned antimalarial compounds, and details the necessary extensions to the basic modeling process that were required in order to accommodate multiple responses and multiple observation phases (pregnant and postpartum). DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves TI - Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves UR - http://hdl.handle.net/11427/10719 ER - en_ZA


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