Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis

 

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dc.contributor.advisor Wilkinson, Robert J en_ZA
dc.contributor.advisor Wilkinson, Katalin en_ZA
dc.contributor.author Gideon, Hannah Priyadarshini en_ZA
dc.date.accessioned 2014-12-30T06:34:33Z
dc.date.available 2014-12-30T06:34:33Z
dc.date.issued 2010 en_ZA
dc.identifier.citation Gideon, H. 2010. Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/10500
dc.description.abstract Studies on Mycobacterium tuberculosis (MTB) antigens are important to improve immunodiagnostics and vaccine efficacy. A novel genome based strategy for antigen discovery is to relate what is highly expressed by bacilli in vivo or in vitro, to what is recognized by human T cells as antigens. As hypoxia is a relevant stimulus that MTB encounters in vivo, whole genome based transcriptional profiles of M. tuberculosis subject to prolonged hypoxia (described as the Enduring hypoxic response (EHR) were analyzed, to guide the discovery of novel potential anitgens, by a combined bioinformatic and empirical approach and to determine evidence of infection stage specific recognition. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medical Microbiology en_ZA
dc.title Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Medical Microbiology en_ZA
dc.type.qualificationlevel Doctoral en_ZA
dc.type.qualificationname PhD en_ZA
uct.type.filetype Text
uct.type.filetype Image


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