Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase

 

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dc.contributor.advisor Meissner, Peter en_ZA
dc.contributor.advisor Corrigall, Anne en_ZA
dc.contributor.author Boateng, Mavis O en_ZA
dc.date.accessioned 2014-12-26T14:17:56Z
dc.date.available 2014-12-26T14:17:56Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Boateng, M. 2011. Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/10131
dc.description.abstract This dissertation focuses on protoporphyrinogen oxidase (PPOX), the penultimate enzyme in the haem biosynthetic pathway. Partial defects in PPOX result in variegate porphyria, an autosomal dominant disorder. PPOX catalyzes the six electron oxidation of protoporphyrinogen IX to protoporphyrin IX, in the presence of flavin adenine dinucleotide (FAD) and oxygen. FAD is a cofactor, functioning as an intermediate electron acceptor in the catalytic function of PPOX. In this study the FAD binding region in Myxococcus xanthus PPOX was analysed by engineering and characterising a selection of relevant mutants. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medicine en_ZA
dc.title Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase en_ZA
dc.type Thesis / Dissertation en_ZA
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Department of Medicine en_ZA
dc.type.qualificationlevel Masters en_ZA
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image


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