Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer

 

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dc.contributor.advisor Parker, M Iqbal en_ZA
dc.contributor.author Bick, Alexis J en_ZA
dc.date.accessioned 2014-12-26T14:16:51Z
dc.date.available 2014-12-26T14:16:51Z
dc.date.issued 2011 en_ZA
dc.identifier.citation Bick, A. 2011. Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer. University of Cape Town. en_ZA
dc.identifier.uri http://hdl.handle.net/11427/10124
dc.description Includes bibliographical references (p. 125-140). en_ZA
dc.description.abstract Tobacco smoking is a major risk factor in the development of oesophageal squamous cell carcinoma (OSCC). Benzo[a]pyrene (BaP) is a tobacco smoke procarcinogen that is metabolically activated into the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor (AhR) which activates CYP1 gene transcription. Polymorphisms in these genes affect enzyme activity and therefore BaP bioactivation. en_ZA
dc.language.iso eng en_ZA
dc.subject.other Medical Biochemistry en_ZA
dc.title Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer en_ZA
dc.type Master Thesis
uct.type.publication Research en_ZA
uct.type.resource Thesis en_ZA
dc.publisher.institution University of Cape Town
dc.publisher.faculty Faculty of Health Sciences en_ZA
dc.publisher.department Division of Medical Biochemistry en_ZA
dc.type.qualificationlevel Masters
dc.type.qualificationname MSc en_ZA
uct.type.filetype Text
uct.type.filetype Image
dc.identifier.apacitation Bick, A. J. (2011). <i>Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry. Retrieved from http://hdl.handle.net/11427/10124 en_ZA
dc.identifier.chicagocitation Bick, Alexis J. <i>"Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2011. http://hdl.handle.net/11427/10124 en_ZA
dc.identifier.vancouvercitation Bick AJ. Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Biochemistry, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10124 en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Bick, Alexis J AB - Tobacco smoking is a major risk factor in the development of oesophageal squamous cell carcinoma (OSCC). Benzo[a]pyrene (BaP) is a tobacco smoke procarcinogen that is metabolically activated into the carcinogenic benzo[a]pyrene diol-epoxide (BPDE) by the CYP1 family of cytochrome P450 enzymes. BaP is a ligand for the aryl hydrocarbon receptor (AhR) which activates CYP1 gene transcription. Polymorphisms in these genes affect enzyme activity and therefore BaP bioactivation. DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer TI - Investigation into the effects of the tobacco smoke procarcinogen benzo[a]pyrene on gene expression profiles in oesophageal cancer UR - http://hdl.handle.net/11427/10124 ER - en_ZA


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