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Browsing by Author "Woodman, Zenda"

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Can one size fit all? Approach to bacterial vaginosis in sub-Saharan Africa

Author: Woodman, Zenda Date: 11 Mar 2016 Bacterial vaginosis (BV) is the most common vaginal disorder affecting women of reproductive age and is associated with increased risk of sexually transmitted infections such as human immunodeficiency syndrome (HIV-1). Sub-Saharan Africa has ... Read more c b
Characterisation of HIV-1 subtype C envelope functional determinants of dual infected individuals

Author: Omar, Shatha Sultan Ahmed Date: 2018 Identification of HIV-1 Envelope (Env) fitness determinants could provide functionally constrained, accessible regions that could be included in subunit vaccines to induce broadly neutralising antibodies (bnAb). We hypothesised that Env fitness ... Read more
Characterisation of the ectodomain shedding of angiotensin-converting enzyme

Author: Woodman, Zenda Date: 2003 Bibliography: leaves 240-266. Read more
Characterisation of the HIV inhibitory activity of vaginal lactobacilli isolates from young South African women at high risk of HIV acquisition

Author: Manhanzva, Monalisa Tatenda Date: 2020 Bacterial vaginosis (BV) is an important predisposing factor for the acquisition of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs) in South African women. However, the microbial causes and the immunomodulatory ... Read more
Characterisation of α4β7and DC-SIGN reactivity of HIV-1 subtype C transmitted founder variants compared with chronic infection controls

Author: Bernitz, Netanya Date: 2014 Includes bibliographical references. Read more
Characterization of genotypic and phenotypic properties of transmitted Human Immunodeficiency virus type 1 variants circulating in Mbeya Tanzania

Author: Nofemela, Andile Date: 2013 Includes abstract. Includes bibliographical references. Read more
Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences

Author: Ngandu, Nobubelo ; Scheffler, Konrad ; Moore, Penny ; Woodman, Zenda ; Martin, Darren ; Seoighe, Cathal Date: 2008 BACKGROUND: Positive selection pressure acting on protein-coding sequences is usually inferred when the rate of nonsynonymous substitution is greater than the synonymous rate. However, purifying selection acting directly on the nucleotide ... Read more c b
HIV-1 subtype C Envelope function becomes less sensitive to N-glycosylation deletion during disease progression

Author: Lumngwena, Evelyn N ; Shuping, Liliwe ; Bernitz, Netanya ; Woodman, Zenda Date: 17 Jun 2019 Objective As part of a larger study to understand how Envelope N-glycosylation influences HIV-1 pathogenesis, we selected a participant infected with a single Subtype C variant and determined whether deletion of specific ... Read more
HIV-1 subtype C transmitted founders modulate dendritic cell inflammatory responses

Author: Lumngwena, Evelyn N ; Metenou, Simon ; Masson, Lindi ; Cicala, Claudia ; Arthos, James ; Woodman, Zenda Date: 02 Jul 2020 Background Heterosexual transmission remains the main route of HIV-1 transmission and female genital tract (FGT) inflammation increases the risk of infection. However, the mechanism(s) by which inflammation facilitates infection is not fully ... Read more c b
The impact of HIV-1 subtype C Envelope N-glycosylation on DC-SIGN meditated modulation of DC function to facilitate transmission or enhance viral pathogenesis

Author: Lumngwena, Evelyn Ngwa Date: 2017 N-glycosylation plays an important role in Envelope (Env) function and may be involved in the modulation of the immune response to HIV-1 infection. In this study, we hypothesized that Env N-glycosylation may affect viral pathogenesis by ... Read more
Neutralizing antibody responses in HIV-1 dual infection : lessons for vaccine design

Author: Sheward, Daniel James Date: 2013 Includes abstract. Includes bibliographical references. Read more
The role of bacterial vaginosis-associated sialidase on HIV-1 infection

Author: Traviss, Riley James Date: 2022 Studies suggest that women with Bacterial Vaginosis (BV) are at a higher risk of being infected by HIV-1. One possible reason is that bacterial vaginosis-associated bacteria (BVAB) release sialidases which alter either the virus and host cells ... Read more
The role of HIV-1 subtype B Envelope transmission motifs in subtype C variant infectivity

Author: Meyer, Bahiah Date: 2018 Transmitted founders (TF) might carry motifs that provide a phenotypic advantage that enables human immunodeficiency virus type-1 (HIV-1) to overcome immune barriers within the female genital tract. One study compared over 5000 subtype B TF ... Read more
To compare the expression, processing, incorporation and function of pseudoviruses and infectious molecular clones using different cell types and HIV backbones

Author: Abrahams, Bianca Date: 2019 Understanding HIV transmission mechanisms is essential for the design and development of an efficacious, broadly acting vaccine that targets features common to transmitted viruses. However, there is a lack of consensus amongst current HIV ... Read more
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage

Author: Chopera, Denis R ; Woodman, Zenda ; Mlisana, Koleka ; Mlotshwa, Mandla ; Martin, Darren P ; Seoighe, Cathal ; Treurnicht, Florette ; Rosa, Debra Assis de ; Hide, Winston ; Karim, Salim Abdool Date: 2008 Author Summary Following infection with HIV, it is well established that a person's genetic makeup is a major determinant of how quickly they will progress to AIDS. Particularly important is the class I Human leukocyte antigen (HLA) gene that ... Read more c b

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