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Browsing by Author "Williamson, C"

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Beneficial HLA-mediated viral polymorphisms on the transmitted virus additively influence disease progression in HIV-1, subtype C infection

Author: Ntale, R S ; Chopera, D R ; Ngandu, N K ; Abrahams, M ; Debra, A ; Mlotswa, M ; Werner, L ; Woodman, Z ; Mlisana, K ; Karim, S ; Gray, CM ; Williamson, C ; CAPRISA 002 AI Study Team Date: 2012 Transmitted viral factors have been shown to affect disease progression but whether infection with viruses carrying beneficial HLA-mediated escape polymorphisms affects disease progression in HLA-mismatched participants remains controversial. Read more c b
Characterization of envelope function of transmitted viruses circulating in Mbeya, Tanzania, and its impact on disease progression

Author: Nofemela, A ; Bandawe, G ; Thebus, R ; Marais, J ; Maboko, L ; Hoelscher, M ; Williamson, C ; Woodman, Z Date: 2012 An understanding of the biological characteristics of transmitted viruses provides important insights into HIV pathogenesis and informs vaccine development. The aim of the study was to characterize env function of transmitted viruses and its ... Read more c b
HIV type 1 subtype C gag and nef diversity in Southern Africa.

Author: Bredell, Helba ; Martin, Darren P ; Van Harmelen Joanne ; Varsani, Arvind ; Sheppard, Haynes W ; Donovan, R ; Gray, C ; HIVNET028 Study Team ; Williamson, C Date: 2007 Several HIV-1 subtype C-specific gag- and/or nef-based vaccines are currently intended for clinical trial in southern Africa. Here we provide sequences of 64 gag and 45 nef genes sampled in Malawi, Zambia, Zimbabwe, and South Africa and assess ... Read more
Increased differentiation associates with decreased polyfunctionality for HIV but not CMV-specific CD8+ T cell responses

Author: Riou, C ; Abrahams, M ; Mlisana, K ; Koup, R ; Roederer, M ; Karim, S ; de Bruyn, G ; Williamson, C ; Gray, CM ; Burgers, WA Date: 2012 The generation of polyfunctional CD8+ T cells, in response to vaccination or natural infection, has been associated with improved protective immunity. However, it remains unclear whether the maintenance of polyfunctionality is linked to ... Read more c b
The recognition of HIV-1 consensus group M Gag and Nef peptide reagents in mono- and multi-clade epidemics: implications for HIV vaccine design

Author: Zembe, L ; Tongo, M ; Ebong, E ; Ngobe, EM ; Williamson, C ; Burgers, W Date: 2012 The high level of genetic diversity of HIV-1 poses a major challenge for global vaccine development. Vaccines based on centralized sequences would minimize genetic distances to multiple clades and potentially maximize cross-reactivity. Whether ... Read more c b
A single dose of SAAVI MVA-C reboosts rhesus macaques after more than 3 years post DNA-MVA prime-boost vaccination

Author: Chege, GK ; Burgers, W ; Muller, T ; Shephard, EG ; Williamson, C ; Williamson, A Date: 2012 We have previously reported induction of robust immune responses in rhesus macaques following a prime boost immunization with candidate HIV-1 vaccines, SAAVI DNA-C (DNA) and SAAVI MVA-C (MVA). These vaccines are already in clinical evaluation. ... Read more c b

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Browsing by Author "Williamson, C"

Browsing by Author "Williamson, C"

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