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Browsing by Author "Warren, Robin"

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Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden

Author: van Zyl-Smit, Richard N ; Binder, Anke ; Meldau, Richard ; Mishra, Hridesh ; Semple, Patricia L ; Theron, Grant ; Peter, Jonathan ; Whitelaw, Andrew ; Sharma, Suren K ; Warren, Robin ; Bateman, Eric D ; Dheda, Keertan Date: 2011 Introduction: Accurate quantification of mycobacterial load is important for the evaluation of patient infectiousness, disease severity and monitoring treatment response in human and in-vitro laboratory models of disease. We hypothesized that ... Read more c b
Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak

Author: Chege, Gerald ; Warren, Robin ; van Pittius, Nico ; Burgers, Wendy ; Wilkinson, Robert ; Shephard, Enid ; Williamson, Anna-Lise Date: 2008 BACKGROUND:Both tuberculous and non-tuberculous mycobacteria can cause infection in nonhuman primates (NHP), indicating the existence of potential zoonotic transmission between these animals and visitors to zoos or animal handlers in primate ... Read more c b
Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa

Author: Shean, Karen ; Streicher, Elizabeth ; Pieterson, Elize ; Symons, Greg ; van Zyl Smit, Richard ; Theron, Grant ; Lehloenya, Rannakoe ; Padanilam, Xavier ; Wilcox, Paul ; Victor, Tommie C ; van Helden Paul ; Groubusch Martin ; Warren, Robin ; Badri, Motasim ; Dheda, Keertan Date: 2013 BACKGROUND: Treatment-related outcomes in patients with extensively drug-resistant tuberculosis (XDR-TB) are poor. However, data about the type, frequency and severity of presumed drug-associated adverse events (AEs) and their association ... Read more c b
High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South african patients with extensively drug-resistant tuberculosis

Author: Pietersen, Elize ; Peter, Jonny ; Streicher, Elizabeth ; Sirgel, Frik ; Rockwood, Neesha ; Mastrapa, Barbara ; Te Riele, Julian ; Davids, Malika ; van Helden, Paul ; Warren, Robin ; Dheda, Keertan Date: 2015 BACKGROUND: There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin achieves high serum concentrations relative to MIC but whether capreomycin ... Read more c b
High yield of culture-based diagnosis in a TB-endemic setting

Author: Demers, Anne-Marie ; Verver, Suzanne ; Boulle, Andrew ; Warren, Robin ; van Helden, Paul ; Behr, Marcel ; Coetzee, David Date: 2012 BACKGROUND: In most of the world, microbiologic diagnosis of tuberculosis (TB) is limited to microscopy. Recent guidelines recommend culture-based diagnosis where feasible. METHODS: In order to evaluate the relative and absolute incremental ... Read more c b

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Browsing by Author "Warren, Robin"

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