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Browsing by Author "Vogt, Monica"

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Blood neutrophil counts in HIV-infected patients with pulmonary tuberculosis: association with sputum mycobacterial load

Author: Kerkhoff, Andrew D ; Wood, Robin ; Lowe, David M ; Vogt, Monica ; Lawn, Stephen D Date: 2013 BACKGROUND: Increasing evidence suggests that neutrophils play a role in the host response to Mycobacterium tuberculosis . We determined whether neutrophil counts in peripheral blood are associated with tuberculosis (TB) and with mycobacterial ... Read more c b
Determine TB-LAM point-of-care tuberculosis assay predicts poor outcomes in outpatients during their first year of antiretroviral therapy in South Africa

Author: Kerkhoff, Andrew D ; Longley, Nicky ; Kelly, Nicola ; Cross, Anna ; Vogt, Monica ; Wood, Robin ; Hermans, Sabine ; Lawn, Stephen D ; Harrison, Thomas S Date: 31 Jul 2020 Abstract Background Determine TB-LAM is the first point-of-care test (POC) for HIV-associated tuberculosis (TB) and rapidly identifies TB in those at high-risk for short-term mortality. While the relationship between urine-LAM and mortality ... Read more
HIV-associated tuberculosis: relationship between disease severity and the sensitivity of new sputum-based and urine-based diagnostic assays

Author: Lawn, Stephen ; Kerkhoff, Andrew ; Vogt, Monica ; Wood, Robin Date: 2013 BACKGROUND: Reducing mortality from HIV-associated tuberculosis (TB) requires diagnostic tools that are rapid and have high sensitivity among patients with poor prognosis. We determined the relationship between disease severity and the ... Read more c b
Lipoarabinomannan in urine during tuberculosis treatment: association with host and pathogen factors and mycobacteriuria

Author: Wood, Robin ; Racow, Kimberly ; Bekker, Linda-Gail ; Middelkoop, Keren ; Vogt, Monica ; Kreiswirth, Barry ; Lawn, Stephen Date: 2012 BACKGROUND:Detection of lipoarabinomannan (LAM), a Mycobacterium tuberculosis (Mtb) cell wall antigen, is a potentially attractive diagnostic. However, the LAM-ELISA assay has demonstrated variable sensitivity in diagnosing TB in diverse ... Read more c b
Plasma levels of soluble urokinase-type plasminogen activator receptor (suPAR) and early mortality risk among patients enrolling for antiretroviral treatment in South Africa

Author: Lawn, Stephen ; Myer, Landon ; Bangani, Nonzwakazi ; Vogt, Monica ; Wood, Robin Date: 2007 Background: Serum concentrations of soluble urokinase-type plasminogen activator receptor (suPAR) have a strong independent association with HIV-1-related mortality. The practical utility of plasma suPAR in assessing short-term all-cause ... Read more c b
Prognostic value of a quantitative analysis of lipoarabinomannan in urine from patients with HIV-associated tuberculosis

Author: Kerkhoff, Andrew D ; Wood, Robin ; Vogt, Monica ; Lawn, Stephen D Date: 2014 BACKGROUND: Detection of the mycobacterial cell wall antigen lipoarabinomannan (LAM) in urine can be used to diagnose HIV-associated tuberculosis (TB) using a qualitative (positive/negative) read-out. However, it is not known whether the ... Read more c b
Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study

Author: Lawn, Stephen D ; Brooks, Sophie V ; Kranzer, Katharina ; Nicol, Mark P ; Whitelaw, Andrew ; Vogt, Monica ; Bekker, Linda-Gail ; Wood, Robin Date: 2011 Background: The World Health Organization has endorsed the Xpert MTB/RIF assay for investigation of patients suspected of having tuberculosis (TB). However, its utility for routine TB screening and detection of rifampicin resistance among ... Read more c b
Utility of interferon-gamma ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa

Author: Lawn, Stephen ; Bangani, Nonzwakazi ; Vogt, Monica ; Bekker, Linda-Gail ; Badri, Motasim ; Ntobongwana, Marjorie ; Dockrell, Hazel ; Wilkinson, Robert ; Wood, Robin Date: 2007 BACKGROUND:Interferon-gamma (IFN-gamma) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with advanced HIV is ... Read more c b

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