Author:Varsani, Arvind; Williamson, Anna-Lise; Jaffer, Mohamed A; Rybicki, Edward PDate:2006Recombinant human papillomavirus (HPV) virus-like particles (VLPs) made from the major capsid protein L1 are promising vaccine candidates for use as vaccines against genital and other HPV infections, and particularly against HPV-16. However, ...Read more
Author:Dent,Kyle ClaytonDate:2014Maize streak virus (MSV), circular single stranded DNA (ssDNA) virus (~2.7kb), is the causative agent of Maize streak disease, and is a devastating pathogen that causes severe crop losses to subsistence farmers in sub-Saharan Africa. MSV is ...Read more
Author:Varsani, ArvindDate:2003The objective of this thesis was to investigate novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of ...Read more
Author:van der Walt, Eric; Martin, Darren; Varsani, Arvind; Polston, Jane; Rybicki, EdwardDate:2008BACKGROUND: Recent reports have indicated that single-stranded DNA (ssDNA) viruses in the taxonomic families Geminiviridae, Parvoviridae and Anellovirus may be evolving at rates of ~10-4 substitutions per site per year (subs/site/year). These ...Read morecb