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Browsing by Author "Theron, Grant"

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Can point-of-care urine LAM strip testing for tuberculosis add value to clinical decision making in hospitalised HIV-infected persons

Author: Peter, Jonathan G ; Theron, Grant ; Dheda, Keertan Date: 2013 BACKGROUND: The urine lipoarabinomannan (LAM) strip-test (Determine®-TB) can rapidly rule-in TB in HIV-infected persons with advanced immunosuppression. However, given high rates of empiric treatment amongst hospitalised patients in high-burden ... Read more c b
Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden

Author: van Zyl-Smit, Richard N ; Binder, Anke ; Meldau, Richard ; Mishra, Hridesh ; Semple, Patricia L ; Theron, Grant ; Peter, Jonathan ; Whitelaw, Andrew ; Sharma, Suren K ; Warren, Robin ; Bateman, Eric D ; Dheda, Keertan Date: 2011 Introduction: Accurate quantification of mycobacterial load is important for the evaluation of patient infectiousness, disease severity and monitoring treatment response in human and in-vitro laboratory models of disease. We hypothesized that ... Read more c b
Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-γ for the evaluation of pleural tuberculosis: a prospective cohort study

Author: Meldau, Richard ; Peter, Jonny ; Theron, Grant ; Calligaro, Greg ; Allwood, Brian ; Symons, Greg ; Khalfey, Hoosain ; Ntombenhle, Gina ; Govender, Ureshnie ; Binder, Anke ; van Zyl-Smit, Richard ; Dheda, Keertan Date: 08 Apr 2014 Background: The accuracy of currently available same-day diagnostic tools (smear microscopy and conventional nucleic acid amplification tests) for pleural tuberculosis (TB) is sub-optimal. Newer technologies may offer improved detection. ... Read more c b
Correlation of mycobacterium tuberculosis specific and non-specific quantitative Th1 T-cell responses with bacillary load in a high burden setting

Author: Theron, Grant ; Peter, Jonny ; Lenders, Laura ; van Zyl-Smit, Richard ; Meldau, Richard ; Govender, Ureshnie ; Dheda, Keertan Date: 2012 BACKGROUND: Measures of bacillary load in patients with tuberculosis (TB) may be useful for predicting and monitoring response to treatment. The relationship between quantitative T-cell responses and mycobacterial load remains unclear. We ... Read more c b
Development of a simple reliable radiographic scoring system to aid the diagnosis of pulmonary tuberculosis

Author: Pinto, Lancelot M ; Dheda, Keertan ; Theron, Grant ; Allwood, Brian ; Calligaro, Gregory ; van Zyl-Smit, Richard ; Peter, Jonathan ; Schwartzman, Kevin ; Menzies, Dick ; Bateman, Eric ; Pai, Madhukar ; Dawson, Rodney Date: 2013 Rationale: Chest radiography is sometimes the only method available for investigating patients with possible pulmonary tuberculosis (PTB) with negative sputum smears. However, interpretation of chest radiographs in this context lacks specificity ... Read more c b
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study

Author: Patel, Vinod B ; Theron, Grant ; Lenders, Laura ; Matinyena, Brian ; Connolly, Cathy ; Singh, Ravesh ; Coovadia, Yacoob ; Ndung'u, Thumbi ; Dheda, Keertan Date: 2013 Background: Tuberculous meningitis (TBM) is difficult to diagnose promptly. The utility of the Xpert MTB/RIF test for the diagnosis of TBM remains unclear, and the effect of host- and sample-related factors on test performance is unknown. ... Read more c b
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

Author: Pandie, Shaheen ; Peter, Jonathan G ; Kerbelker, Zita S ; Meldau, Richard ; Theron, Grant ; Govender, Ureshnie ; Ntsekhe, Mpiko ; Dheda, Keertan ; Mayosi, Bongani M Date: 18 Jun 2014 Background: Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. ... Read more
The diagnostic accuracy of urine-based Xpert MTB/RIF in HIV-infected hospitalized patients who are smear-negative or sputum scarce

Author: Peter, Jonathan G ; Theron, Grant ; Muchinga, Tapuwa E ; Govender, Ureshnie ; Dheda, Keertan Date: 2012 BACKGROUND: Hospitals in sub-Saharan Africa are inundated with HIV-infected patients and tuberculosis (TB) is the commonest opportunistic infection in this sub-group. Up to one third of TB-HIV co-infected patients fail to produce a sputum ... Read more c b
Diagnostic and therapeutic biomarker responses in HIV and tuberculosis co-infected patients

Author: Mthiyane, Thuli Carol Penelope Date: 2020 Introduction: Biomarkers of tuberculosis (TB) diagnosis and treatment response in patients coinfected with human immunodeficiency virus (HIV) are a necessity to ensure early diagnosis and adequate monitoring of TB treatment response. We ... Read more
Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa

Author: Shean, Karen ; Streicher, Elizabeth ; Pieterson, Elize ; Symons, Greg ; van Zyl Smit, Richard ; Theron, Grant ; Lehloenya, Rannakoe ; Padanilam, Xavier ; Wilcox, Paul ; Victor, Tommie C ; van Helden Paul ; Groubusch Martin ; Warren, Robin ; Badri, Motasim ; Dheda, Keertan Date: 2013 BACKGROUND: Treatment-related outcomes in patients with extensively drug-resistant tuberculosis (XDR-TB) are poor. However, data about the type, frequency and severity of presumed drug-associated adverse events (AEs) and their association ... Read more c b
Novel and newer nucleic acid amplification tests for the diagnosis of TB

Author: Matinyenya, Brian Date: 2016 Background: Current tools for TB diagnosis have suboptimal accuracy, perform poorly in diagnosing extra-pulmonary TB, and are not point of care; hence results have a slow turn-around time. Objective: This project evaluated the diagnostic ... Read more
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study

Author: Theron, Grant ; Peter, Jonny ; Zijenah, Lynn ; Chanda, Duncan ; Mangu, Chacha ; Clowes, Petra ; Rachow, Andrea ; Lesosky, Maia ; Hoelscher, Michael ; Pym, Alex ; Mwaba, Peter ; Mason, Peter ; Naidoo, Pamela ; Pooran, Anil ; Sohn, Hojoon ; Pai, Madhukar ; Stein, Dan Date: 2015 BACKGROUND:The successful cure of tuberculosis (TB) is dependent on adherence to treatment. Various factors influence adherence, however, few are easily modifiable. There are limited data regarding correlates of psychological distress and ... Read more c b
The relationship between chest X-ray findings, bacterial load and treatment-related outcomes in persons with extensively drug resistant TB

Author: Te Riele, Julian Bernard Date: 2014 Multi-drug resistant tuberculosis (MDR-TB) was first recognized in the 1990s with an increase in caseload of eighty-two percent between 2000 and 2007. Extensively drug-resistant tuberculosis (XDR-TB), a more difficult and more expensive form ... Read more
Test characteristics and potential impact of the urine LAM lateral flow assay in HIV-infected outpatients under investigation for TB and able to self-expectorate sputum for diagnostic testing

Author: Peter, Jonny ; Theron, Grant ; Chanda, Duncan ; Clowes, Petra ; Rachow, Andrea ; Lesosky, Maia ; Hoelscher, Michael ; Mwaba, Peter ; Pym, Alex ; Dheda, Keertan ; For the TB-NEAT team Date: 2015 BACKGROUND: The commercially available urine LAM strip test, a point-of-care tuberculosis (TB) assay, requires evaluation in a primary care setting where it is most needed. There is currently inadequate data to guide implementation in TB and ... Read more c b
What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa

Author: Pooran, Anil ; Pieterson, Elize ; Davids, Malika ; Theron, Grant ; Dheda, Keertan Date: 2013 BACKGROUND: Drug-resistant tuberculosis (DR-TB) is undermining TB control in South Africa. However, there are hardly any data about the cost of treating DR-TB in high burden settings despite such information being quintessential for the ... Read more c b

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