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Browsing by Author "Stein, Dan J"

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An integrative approach to psychiatric diagnosis and research

Author: Stein, Dan J Date: 2014 Much attention has been paid to revisions of psychiatric classification systems. Nevertheless, there remains significant dissatisfaction with the nosology. From a neuroscience perspective, diagnostic criteria have failed to incorporate ... Read more
Assessing post-traumatic stress disorder in South African adolescents: using the child and adolescent trauma survey (CATS) as a screening tool

Author: Suliman, S ; Kaminer, D ; Seedat, Soraya ; Stein, Dan J Date: 2005 BACKGROUND:Several studies have demonstrated that South African children and adolescents are exposed to high levels of violent trauma with a significant proportion developing PTSD, however, limited resources make it difficult to accurately ... Read more c b
The assessment and treatment of panic disorder in general practice

Author: Koen, N ; Stein, Dan J Date: 2012 Panic disorder (PD) is an anxiety disorder that affects many South Africans. If undiagnosed or mismanaged, this condition may impact profoundly on an individual's functioning and quality of life. At the primary level, the assessment of panic ... Read more c b n d
The association between aids related stigma and major depressive disorder among HIV-positive individuals in Uganda

Author: Akena, Dickens ; Musisi, Seggane ; Joska, John ; Stein, Dan J Date: 2012 BACKGROUND: Major depressive disorder in people living with HIV/AIDS (PLWHA) is common and may be associated with a number of factors, including AIDS-related stigma, decreased CD4 levels, increased opportunistic infections and sociodemographic ... Read more c b
The association between hypertension and depression and anxiety disorders: results from a nationally-representative sample of South African adults

Author: Grimsrud, Anna ; Stein, Dan J ; Seedat, Soraya ; Williams, David ; Myer, Landon Date: 2009 Objective: Growing evidence suggests high levels of comorbidity between hypertension and mental illness but there are few data from low- and middle-income countries. We examined the association between hypertension and depression and anxiety ... Read more c b
Associations between lifetime potentially traumatic events and chronic physical conditions in the South African Stress and Health Survey: a cross-sectional study

Author: Atwoli, Lukoye ; Platt, Jonathan M ; Basu, Archana ; Williams, David R ; Stein, Dan J ; Koenen, Karestan C Date: 07 Jul 2016 Background: This study examined the association between the type, and cumulative number of lifetime potentially traumatic events (PTEs), and chronic physical conditions, in a South African sample. PTE exposures have been associated with an ... Read more c b
The BDNF p.Val66Met polymorphism, childhood trauma, and brain volumes in adolescents with alcohol abuse

Author: Dalvie, Shareefa ; Stein, Dan J ; Koenen, Karestan ; Cardenas, Valerie ; Cuzen, Natalie L ; Ramesar, Raj ; Fein, George ; Brooks, Samantha J Date: 16 Dec 2014 Background: Previous studies have indicated that early life adversity, genetic factors and alcohol dependence are associated with reduced brain volume in adolescents. However, data on the interactive effects of early life adversity, genetic ... Read more c b
BDNF polymorphisms are linked to poorer working memory performance, reduced cerebellar and hippocampal volumes and differences in prefrontal cortex in a Swedish elderly population

Author: Brooks, Samantha J ; Nilsson, Emil K ; Jacobsson, Josefin A ; Stein, Dan J ; Fredriksson, Robert ; Lind, Lars ; Schiöth, Helgi B Date: 2014 BACKGROUND: Brain-derived neurotrophic factor (BDNF) links learning, memory and cognitive decline in elderly, but evidence linking BDNF allele variation, cognition and brain structural differences is lacking. METHODS: 367 elderly Swedish men ... Read more c b
Blushing and gaze avoidance in social anxiety disorder : a structural neuroanatomical investigation

Author: Van der Merwe, Nicolina Thandiwe Date: 2014 Background: Social anxiety disorder (SAD) is a common psychiatric condition characterised by fear and avoidance of social situations. Lifetime prevalence is 5-16% and co-morbidity with other mood and substance abuse disorders is common. ... Read more
Challenges faced by South African health services in implementing the Mental Health Care Act

Author: Lund, C ; Stein, Dan J ; Flisher, A J ; Mehtar, S Date: 2007 The World Health Organization (WHO) has drawn attention to the growing global burden of mental disorders, and to recent advances in our understanding of and ability to treat these disorders. Mental disorders accounted for 12% of the global ... Read more
Comparing dedicated and designated models of integrating mental health into chronic disease care: study protocol for a cluster randomized controlled trial

Author: Myers, Bronwyn ; Lund, Crick ; Lombard, Carl ; Joska, John ; Levitt, Naomi ; Butler, Christopher ; Cleary, Susan ; Naledi, Tracey ; Milligan, Peter ; Stein, Dan J ; Sorsdahl, Katherine Date: 16 Mar 2018 Background In low- and middle-income countries (LMIC), it is uncertain whether a “dedicated” approach to integrating mental health care (wherein a community health worker (CHW) has the sole responsibility of delivering mental ... Read more c b
Dealing with post-traumatic stress disorder in general practice

Author: Suliman, S ; Stein, Dan J Date: 2012 Traumatic experiences are prevalent in South Africa and may result in psychiatric disorders such as post-traumatic stress disorder (PTSD). PTSD is accompanied by a range of psychobiological alterations, including changes in brain structure ... Read more c b n d
Dealing with substance use disorders in general practice

Author: Pasche, S C ; Stein, Dan J Date: 2012 Substance use disorders are highly prevalent in South Africa. General practitioners are often the first point of contact and play an essential role in correctly identifying the substance use problem. This article provides an overview of the ... Read more c b n d
Developmental stress elicits preference for methamphetamine in the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder

Author: Womersley, Jacqueline S ; Mpeta, Bafokeng ; Dimatelis, Jacqueline J ; Kellaway, Lauriston A ; Stein, Dan J ; Russell, Vivienne A Date: 17 Jun 2016 Background: Developmental stress has been hypothesised to interact with genetic predisposition to increase the risk of developing substance use disorders. Here we have investigated the effects of maternal separation-induced developmental ... Read more c b
A diffusion tensor imaging and neurocognitive study of ART-naïve and ART-treated children in Cape Town

Author: Hoare, Jacqueline Date: 2015 There are still no diagnostic criteria for a spectrum of neurocognitive disorders (ND) secondary to HIV infection for children. The American Academy of Neurology (AAN) proposes guidelines for assessment of HIV associated neurocognitive disorders ... Read more
DSM-IV-defined common mental disorders:association with HIV testing, HIV-related fears, perceived risk and preventive behaviours among South African adults

Author: Myer, Landon ; Stein, Dan J ; Grimsrud, Anna T ; Herman, Allen ; Seedat, Soraya ; Moomal, Hashim ; Williams, David R Date: 2009 Background. There are few reports from South Africa on how common mental disorders may be associated with HIVrelated perceptions and behaviours. Methods. Between 2002 and 2004, 4 351 South African adults were interviewed. Psychiatric diagnoses ... Read more
Escitalopram in the prevention of posttraumatic stress disorder: a pilot randomized controlled trial

Author: Suliman, Sharain ; Seedat, Soraya ; Pingo, Janine ; Sutherland, Taryn ; Zohar, Joseph ; Stein, Dan J Date: 19 Feb 2015 Background: A small literature suggests that pharmacotherapy may be useful in the prophylaxis of posttraumatic stress disorder in patients presenting with major trauma. There is relatively little data, however, on the use of selective serotonin ... Read more c b
Executive functioning in methamphetamine psychosis

Author: Cotton, Sarah May Date: 2014 An association between methamphetamine dependence and neurocognitive impairment has long been established. However, there are a number of research gaps. First, while evidence suggests that the primary cognitive domains affected in methamphetamine ... Read more
Genetic analysis of bipolar disorder and alcohol use disorder

Author: Dalvie, Shareefa Date: 2015 Background: Mental health disorders represent a major public health problem in most countries around the world. In South Africa, the lifetime prevalence of psychiatric disorders is 30.3%, with substance-use disorders and mood disorders being ... Read more
Heroin detoxification during pregnancy: a systematic review and retrospective study of management of heroin addiction in pregnancy

Author: Gilfillan, Katherine Verne Date: 2012 There is a general consensus that methadone maintenance is the gold standard in the management of pregnant heroin users. However, in South African state hospitals, methadone withdrawal is the routine procedure offered to these patients, as ... Read more

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