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Browsing by Author "Semple, Patricia L"

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Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden

Author: van Zyl-Smit, Richard N ; Binder, Anke ; Meldau, Richard ; Mishra, Hridesh ; Semple, Patricia L ; Theron, Grant ; Peter, Jonathan ; Whitelaw, Andrew ; Sharma, Suren K ; Warren, Robin ; Bateman, Eric D ; Dheda, Keertan Date: 2011 Introduction: Accurate quantification of mycobacterial load is important for the evaluation of patient infectiousness, disease severity and monitoring treatment response in human and in-vitro laboratory models of disease. We hypothesized that ... Read more c b
Feasibility and diagnostic utility of antigen-specific interferon-gamma responses for rapid immunodiagnosis of tuberculosis using induced sputum

Author: Cashmore, Tamaryn J ; Peter, Jonathan G ; Van Zyl-Smit, Richard N ; Semple, Patricia L ; Maredza, Alice ; Meldau, Richard ; Zumla, Alimuddin ; Nurse, Barbara ; Dheda, Keertan Date: 2010 BACKGROUND: The diagnosis of smear-negative or sputum-scarce tuberculosis (TB) is problematic as culture takes several weeks and representative biological samples are difficult to obtain. RD-1 antigen-specific interferon-γ release assays ... Read more c b

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