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Browsing by Author "Ross, Ian Louis"

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9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s Disease

Author: Ross, Ian Louis ; Dandara, Collet ; Swart, Marelize ; Lacerda, Miguel ; Schatz, Desmond ; Blom, Dirk Jacobus Date: 2014 BACKGROUND: Addison’s disease (AD) has been associated with an increased risk of cardiovascular disease. Glucocorticoid receptor polymorphisms that alter glucocorticoid sensitivity may influence metabolic and cardiovascular risk factors in ... Read more c b
Addison's disease symptoms - a cross sectional study in urban South Africa

Author: Ross, Ian Louis ; Levitt, Naomi S Date: 2013 BACKGROUND: Addison's disease is a potentially life-threatening disorder, and prompt diagnosis, and introduction of steroid replacement has resulted in near normal life-expectancy. There are limited data describing the clinical presentation ... Read more c b
The aetiopathogenesis, cardiovascular and metabolic complications, and pharmacogenomics of Addison's disease in South Africa

Author: Ross, Ian Louis Date: 2011 This thesis aimed to address a number of unanswered research questions in Addison's Disease: investigate whether autoimmunity is the predominant cause of Addison's disease in South Africa and if a human leukocyte (HLA) DQ antigen ... Read more
Amiodarone-induced thyroid dysfunction

Author: Ross, Ian Louis ; Marshall, David ; Okreglicki, Andrzej ; Isaacs, Sedick ; Levitt, Naomi Sharlene Date: 2005 Background. Little is known about the frequency of thyroid dysfunction (TD) associated with amiodarone therapy in southern Africa. Objectives. To determine the incidence of TD in a cohort of patients initiated on amiodarone therapy at a cardiac ... Read more
Cardiovascular risk factors in patients with Addison's disease: a comparative study of South African and Swedish patients

Author: Ross, Ian Louis ; Bergthorsdottir, Ragnhildur ; Levitt, Naomi ; Dave, Joel Alex ; Schatz, Desmond ; Marais, David ; Johannsson, Gudmundur Date: 2014 BACKGROUND: Patients with Addison's disease (AD) in Scandinavia have an increased risk for premature death due to cardiovascular disease (CVD). Serum lipids are important risk factors for CVD and vascular mortality. Replacement doses of ... Read more c b
Excessive weight gain following therapy for hyperthyroidism - a major problem

Author: Ross, Ian Louis ; Levitt, Naomi S Date: 2003 One of the most characteristic presenting features of hyperthyroidism is weight loss, despite an increased appetite. This phenomenon is easily understandable, as hyperthyroidism is accompanied by a rise in metabolic rate, energy expenditure ... Read more c b n
Hyperthyroidism: What the generalist should know

Author: Ross, Ian Louis ; Levitt, Naomi S Date: 2003 Thyrotoxicosis is one of the more common endocrine disorders and most cases result from hyperactivity of the thyroid gland (hyperthyroidism) (Table I). Younger patients with thyrotoxicosis of any cause may present with palpitations, anxiety, ... Read more