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Browsing by Author "Raman, Jaishree"

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Absence of kelch13 artemisinin resistance markers but strong selection for lumefantrine-tolerance molecular markers following 18 years of artemisinin-based combination therapy use in Mpumalanga Province, South Africa (2001–2018)

Author: Raman, Jaishree ; Kagoro, Frank M ; Mabuza, Aaron ; Malatje, Gillian ; Reid, Anthony ; Frean, John ; Barnes, Karen I Date: 22 Aug 2019 Abstract Background The ability of Plasmodium falciparum parasites to develop resistance to widely used anti-malarials threatens malaria control and elimination efforts. Regular drug efficacy ... Read more
Efficacy of sulphadoxine-pyrimethamine with or without artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in southern Mozambique: a randomized controlled trial

Author: Allen, Elizabeth N ; Little, Francesca ; Camba, Tunisio ; Cassam, Yasmin ; Raman, Jaishree ; Boulle, Andrew ; Barnes, Karen I Date: 2009 BACKGROUND: An artemisinin-based combination therapy, artesunate (AS) plus sulphadoxine-pyrimethamine (SP), was compared to SP monotherapy to provide evidence of further treatment options in southern Mozambique. METHODS: Between 2003 and 2005, ... Read more c b
Five years of antimalarial resistance marker surveillance in Gaza Province, Mozambique, following artemisinin-based combination therapy roll out

Author: Raman, Jaishree ; Mauff, Katya ; Muianga, Pedro ; Mussa, Abdul ; Maharaj, Rajendra ; Barnes, Karen I Date: 2011 Antimalarial drug resistance is a major obstacle to malaria control and eventual elimination. The routine surveillance for molecular marker of resistance is an efficient way to assess drug efficacy, which remains feasible in areas where malaria ... Read more c b
Safety and tolerability of single low-dose primaquine in a low-intensity transmission area in South Africa: an open-label, randomized controlled trial

Author: Raman, Jaishree ; Allen, Elizabeth ; Workman, Lesley ; Mabuza, Aaron ; Swanepoel, Hendrik ; Malatje, Gillian ; Frean, John ; Wiesner, Lubbe ; Barnes, Karen I Date: 24 Jun 2019 Abstract Background To reduce onward falciparum malaria transmission, the World Health Organization recommends adding single low-dose (SLD) primaquine to artemisinin-based combination treatment ... Read more

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