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Browsing by Author "Pooran, Anil"

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Different screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis

Author: Pooran, Anil ; Booth, Helen ; Miller, Robert F ; Scott, Geoff ; Badri, Motasim ; Huggett, Jim F ; Rook, Graham ; Zumla, Alimuddin ; Dheda, Keertan Date: 2010 BACKGROUND: Previous health economic studies recommend either a dual screening strategy [tuberculin skin test (TST) followed by interferon-gamma-release assay (IGRA)] or a single one [IGRA only] for latent tuberculosis infection (LTBI), the ... Read more c b
Early morning urine collection to improve urinary lateral flow LAM assay sensitivity in hospitalised patients with HIV-TB co-infection

Author: Gina, Phindile ; Randall, Philippa J ; Muchinga, Tapuwa E ; Pooran, Anil ; Meldau, Richard ; Peter, Jonny G ; Dheda, Keertan Date: 12 May 2017 Background: Urine LAM testing has been approved by the WHO for use in hospitalised patients with advanced immunosuppression. However, sensitivity remains suboptimal. We therefore examined the incremental diagnostic sensitivity of early morning ... Read more
Evaluation of the costs of managing cutaneous adverse drug reactions to first-line TB therapy in South African TB patients

Author: Knight, Lauren Kerry Date: 2018 Background: Optimal tuberculosis (TB) treatment remains the backbone of effective TB control programmes. However, TB drugs are often associated with adverse drug reactions (ADR) that affect treatment adherence and cure. Cutaneous adverse drug ... Read more
Increased production of IL-4 and IL-12p40 from bronchoalveolar lavage cells are biomarkers of Mycobacterium tuberculosis in the sputum

Author: Nolan, Anna ; Fajardo, Elaine ; Huie, Maryann L ; Condos, Rany ; Pooran, Anil ; Dawson, Rodney ; Dheda, Keertan ; Bateman, Eric ; Rom, William N ; Weiden, Michael D Date: 2013 BACKGROUND: Tuberculosis (TB) causes 1.45 million deaths annually world wide, the majority of which occur in the developing world. Active TB disease represents immune failure to control latent infection from airborne spread. Acid-fast bacillus ... Read more c b
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study

Author: Theron, Grant ; Peter, Jonny ; Zijenah, Lynn ; Chanda, Duncan ; Mangu, Chacha ; Clowes, Petra ; Rachow, Andrea ; Lesosky, Maia ; Hoelscher, Michael ; Pym, Alex ; Mwaba, Peter ; Mason, Peter ; Naidoo, Pamela ; Pooran, Anil ; Sohn, Hojoon ; Pai, Madhukar ; Stein, Dan Date: 2015 BACKGROUND:The successful cure of tuberculosis (TB) is dependent on adherence to treatment. Various factors influence adherence, however, few are easily modifiable. There are limited data regarding correlates of psychological distress and ... Read more c b
The role of IL-4 and Th2-like cytokines in pulmonary tuberculosis

Author: Pooran, Anil Date: 2015 Tuberculosis (TB) vaccine candidates have been mostly ineffective and it remains unclear as to what constitutes protective host immunity. Despite high levels of IFN-γ at the site of disease, the Th1 cytokine associated with protection, many ... Read more
What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa

Author: Pooran, Anil ; Pieterson, Elize ; Davids, Malika ; Theron, Grant ; Dheda, Keertan Date: 2013 BACKGROUND: Drug-resistant tuberculosis (DR-TB) is undermining TB control in South Africa. However, there are hardly any data about the cost of treating DR-TB in high burden settings despite such information being quintessential for the ... Read more c b

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Browsing by Author "Pooran, Anil"

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