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Browsing by Author "Orrell, Catherine"

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A cluster randomized controlled trial of extending ART refill intervals to six-monthly for anti-retroviral adherence clubs

Author: Wilkinson, Lynne ; Grimsrud, Anna ; Cassidy, Tali ; Orrell, Catherine ; Voget, Jacqueline ; Hayes, Helen ; Keene, Claire ; Steele, Sarah J ; Gerstenhaber, Rodd Date: 30 Jul 2019 Abstract Background The antiretroviral therapy (ART) adherence club (AC) differentiated service delivery model, where clinically stable ART patients receive their ART refills ... Read more
AGILE: a seamless phase I/IIa platform for the rapid evaluation of candidates for COVID-19 treatment: an update to the structured summary of a study protocol for a randomised platform trial letter

Author: Griffiths, Gareth O ; FitzGerald, Richard ; Jaki, Thomas ; Corkhill, Andrea ; Reynolds, Helen ; Ewings, Sean ; Condie, Susannah ; Tilt, Emma ; Johnson, Lucy ; Radford, Mike ; Simpson, Catherine ; Saunders, Geoffrey ; Yeats, Sara ; Mozgunov, Pavel ; Tansley-Hancock, Olana ; Martin, Karen ; Downs, Nichola ; Eberhart, Izabela ; Martin, Jonathan W B ; Goncalves, Cristiana ; Song, Anna ; Fletcher, Tom ; Byrne, Kelly ; Lalloo, David G ; Owen, Andrew ; Jacobs, Michael ; Walker, Lauren ; Lyon, Rebecca ; Woods, Christie ; Gibney, Jennifer ; Chiong, Justin ; Chandiwana, Nomathemba ; Jacob, Shevin ; Lamorde, Mohammed ; Orrell, Catherine ; Pirmohamed, Munir ; Khoo, Saye Date: 26 Jul 2021 Background There is an urgent unmet clinical need for the identification of novel therapeutics for the treatment of COVID-19. A number of COVID-19 late phase trial platforms have been developed to investigate (often repurposed) ... Read more c b
Antiretroviral therapy in a community clinic - early lessons from a pilot project

Author: Bekker, Linda-Gail ; Orrell, Catherine ; Reader, Larissa ; Matoti, Larissa ; Cohen, Karen ; Martell, Rob ; Abdullah, Fareed ; Wood, Robin Date: 2003 Objectives. To report on operational and clinical problems encountered during the first 6 months of a community-based antiretroviral therapy (ART) programme. Methods. ART was implemented in a primary care setting utilising an easily replicable ... Read more c b n
Artesunate and amodiaquine : tolerability and drug interaction study in healthy normal volunteers

Author: Orrell, Catherine Date: 2005 Includes bibliographical references. Read more
Brief psychotherapy administered by non-specialised health workers to address risky substance use in patients with multidrug-resistant tuberculosis: a feasibility and acceptability study

Author: Calligaro, Gregory L ; de Wit, Zani ; Cirota, Jacqui ; Orrell, Catherine ; Myers, Bronwyn ; Decker, Sebastian ; Stein, Dan J ; Sorsdahl, Katherine ; Dawson, Rodney Date: 19 Jan 2021 Background Only 55% of multidrug-resistant tuberculosis (MDR-TB) cases worldwide complete treatment, with problem substance use a risk for default and treatment failure. Nevertheless, there is little research on psychotherapeutic ... Read more c b
Community acceptability of dolutegravir-based HIV treatment in women: a qualitative study in South Africa and Uganda

Author: Alhassan, Yussif ; Twimukye, Adelline ; Malaba, Thoko ; Orrell, Catherine ; Myer, Landon ; Waitt, Catriona ; Lamorde, Mohammed ; Kambugu, Andrew ; Reynolds, Helen ; Khoo, Saye ; Taegtmeyer, Miriam Date: 07 Dec 2020 Abstract Background Despite concerns about dolutegravir use in pregnancy, most low- and middle-income countries are accelerating the introduction of dolutegravir-based regimens into national ... Read more
Comparison of six methods to estimate adherence in an ART-naïve cohort in a resource-poor setting: which best predicts virological and resistance outcomes?

Author: Orrell, Catherine ; Cohen, Karen ; Leisegang, Rory ; Bangsberg, David R ; Wood, Robin ; Maartens, Gary Date: 04 Apr 2017 Background: Incomplete adherence to antiretroviral therapy (ART) results in virologic failure and resistance. It remains unclear which adherence measure best predicts these outcomes. We compared six patient-reported and objective adherence ... Read more
Comparison of six methods to estimate adherence in an ART-naïve cohort in a resource-poor setting: which best predicts virological and resistance outcomes?

Author: Orrell, Catherine ; Cohen, Karen ; Leisegang, Rory ; Bangsberg, David R ; Wood, Robin ; Maartens, Gary Date: 2017 BACKGROUND: Incomplete adherence to antiretroviral therapy (ART) results in virologic failure and resistance. It remains unclear which adherence measure best predicts these outcomes. We compared six patient-reported and objective adherence ... Read more
Engendering health systems in response to national rollout of dolutegravir-based regimens among women of childbearing potential: a qualitative study with stakeholders in South Africa and Uganda

Author: Alhassan, Yussif ; Twimukye, Adelline ; Malaba, Thoko ; Orrell, Catherine ; Myer, Landon ; Waitt, Catriona ; Lamorde, Mohammed ; Kambugu, Andrew ; Reynolds, Helen ; Khoo, Saye ; Taegtmeyer, Miriam Date: 01 Aug 2020 Abstract Background In the era of rapid dolutegravir rollout, concerns about neural tube defects have complicated the health systems response among women of childbearing potential. This qualitative ... Read more
Evaluation of adherence monitoring system using evriMED with a differentiated response compared to standard of care among drug-sensitive TB patients in three provinces in South Africa: a protocol for a cluster randomised control trial

Author: Maraba, Noriah ; Orrell, Catherine ; Chetty-Makkan, Candice M. ; Velen, Kavindhran ; Mukora, Rachel ; Page-Shipp, Liesl ; Naidoo, Pren ; Mbatha, M. T. ; Fielding, Katherine L. ; Charalambous, Salome Date: 09 Jun 2021 Abstract Background South Africa has achieved drug-susceptible TB (DS-TB) treatment success of only 77% among people with new and previously treated TB. Alternative approaches are required to ... Read more
Healthcare utilization of patients accessing an African national treatment program

Author: Harling, Guy ; Orrell, Catherine ; Wood, Robin Date: 2007 BACKGROUND:The roll-out of antiretroviral therapy (ART) in Africa will have significant resource implications arising from its impact on demand for healthcare services. Existing studies of healthcare utilization on HAART have been conducted ... Read more c b
Increasing transfers-out from an antiretroviral treatment service in South Africa: patient characteristics and rates of virological non-suppression

Author: Nglazi, Mweete D ; Kaplan, Richard ; Orrell, Catherine ; Myer, Landon ; Wood, Robin ; Bekker, Linda-Gail ; Lawn, Stephen D Date: 2013 Objectives: To determine the proportion, characteristics and outcomes of patients who transfer-out from an antiretroviral therapy (ART) service in a South African township. METHODS: This retrospective cohort study included all patients aged ... Read more c b
Initiating patients on antiretroviral therapy at CD4 cell counts above 200 cells/Âµl is associated with improved treatment outcomes in South Africa

Author: Zeinecker, Jennifer ; Orrell, Catherine ; Wood, Robin Date: 2010 Observational cohort study. Methods Patients presenting to primary care clinics with CD4 cell counts <350 cells/mm3 were randomized to either doctor- or nurse-managed HIV care and followed for at least two years after ART initiation. ... Read more
Linkage to HIV care and antiretroviral therapy in Cape Town, South Africa

Author: Kranzer, Katharina ; Zeinecker, Jennifer ; Ginsberg, Philip ; Orrell, Catherine ; Kalawe, Nosindiso N ; Lawn, Stephen D ; Bekker, Linda-Gail ; Wood, Robin Date: 2010 BACKGROUND: Antiretroviral therapy (ART) has been scaled-up rapidly in Africa. Programme reports typically focus on loss to follow-up and mortality among patients receiving ART. However, little is known about linkage and retention in care of ... Read more c b
Low prevalence of liver disease but regional differences in HBV treatment characteristics mark HIV/HBV co-infection in a South African HIV clinical trial

Author: Ive, Prudence ; MacLeod, William ; Mkumla, Nompumelelo ; Orrell, Catherine ; Jentsch, Ute ; Wallis, Carole L ; Stevens, Wendy ; Wood, Robin ; Sanne, Ian ; Bhattacharya, Debika Date: 2013 BACKGROUND: Hepatitis B virus (HBV) infection is endemic in South Africa however, there is limited data on the degree of liver disease and geographic variation in HIV/HBV coinfected individuals. In this study, we analysed data from the CIPRA-SA ... Read more c b
Mortality of HIV-infected patients starting antiretroviral therapy in sub-Saharan Africa: comparison with HIV-unrelated mortality

Author: Brinkhof, Martin W G ; Boulle, Andrew ; Weigel, Ralf ; Messou, Eugène ; Mathers, Colin ; Orrell, Catherine ; Dabis, François ; Pascoe, Margaret ; Egger, Matthias ; (IeDEA), for the International epidemiological Databases to Evaluate AIDS Date: 2009 Comparing mortality rates between patients starting HIV treatment and the general population in four African countries, Matthias Egger and colleagues find the gap decreases over time, especially with early treatment. Read more c b
Prevalence of asymptomatic sexually transmitted infections: a retrospective review of screening data from Desmond Tutu HIV Centre clinical trial cohorts from 2012 to 2017, Cape Town

Author: Garnett, Nomcebo Precious Date: 2019 Background: The burden of Sexually transmitted infections (STIs) is high globally. The World Health Organisation (WHO) recommends syndromic management of these STIs, based on presentation with signs and symptoms, in resource-limited countries. ... Read more
Public-health and individual approaches to antiretroviral therapy: township South Africa and Switzerland compared

Author: Keiser, Olivia ; Orrell, Catherine ; Egger, Matthias ; Wood, Robin ; Brinkhof, Martin W G ; Furrer, Hansjakob ; vCutsem, Gilles ; Ledergerber, Bruno ; Boulle, Andrew ; (IeDEA-SA), for the Swiss HIV Cohort Study (SHCS) and the International Epidemiologic Databases Date: 2008 Comparing HIV treatment in Switzerland, where drug selection is individualized, and South Africa, where a programmatic approach is used, Matthias Egger and colleagues find similar virologic outcomes over two years. Read more c b
Rapid scale-up of A community-based HIV treatment service: Programme performance over 3 consecutive years in Guguletu, South Africa

Author: Bekker, Linda-Gail ; Myer, Landon ; Orrell, Catherine ; Lawn, Steve ; Wood, Robin Date: 2006 Background. Despite rapid expansion of antiretroviral therapy (ART) in sub-Saharan Africa there are few longitudinal data describing programme performance during rapid scale-up. Methods. We compared mortality, viral suppression and programme ... Read more
Rates of switching antiretroviral drugs in a primary care service in South Africa before and after introduction of tenofovir

Author: Njuguna, Christine ; Orrell, Catherine ; Kaplan, Richard ; Bekker, Linda-Gail ; Wood, Robin ; Lawn, Stephen D Date: 2013 Introduction Antiretroviral changes (single drug substitutions and regimen switches) limit treatment options and introduce challenges such as increased cost, monitoring and adherence difficulties. Patterns of drug substitutions and regimen ... Read more c b

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