Author:Griffiths, Bradley PaulDate:2014Study Rationale: Good evidence exists to support the use of secondary prevention medications (aspirin, HMG-CoA reductase inhibitors [statins], beta-blockers and angiotensin-converting enzyme inhibitors [ACEIs] or angiotensin receptor blockers ...Read more
Author:Nachega, Jean B; Ntsekhe, Mpiko; Volmink, Jimmy; Thabane, LehanaDate:03 Oct 2018We are deeply saddened by the passing of Professor Bongani Mayosi. Bongani was one of the inaugural board members of Pilot and Feasibility Studies. He contributed greatly to the design and conduct of pilot and feasibility studies in cardiovascular ...Read more
Author:Mbanga, Luyanda CDate:2022Background At least a quarter of patients admitted to the Cardiac Intensive Care Unit (CICU) will develop Acute Kidney Injury (AKI) and some of these patients receive Renal Replacement Therapy (RRT). The clinical profiles and outcomes of CICU ...Read more
Author:Kiggundu, BrianDate:2020Diagnosis of infectious pericardial disease has been challenging in the developing world despite improvement of treatment modalities. The diagnostic utility of pH in diagnosing infectious pericardial fluid is unknown, yet this concept is well ...Read more
Author:Prinsloo, Dawid NicolaasDate:2021Background: The quality of INR control determines the effectiveness and safety of Warfarin. Data on INR control in non-metropolitan settings of South Africa (SA) is sparse. Objectives: To examine the Time in Therapeutic Range (TTR) and its ...Read more
Author:Ntsekhe, Mpiko; Mayosi, Bongani; Gumbo, TawandaDate:2012BACKGROUND:The purpose of this study was to quantify the heterogeneous distribution of echodensities in the pericardial fluid of patients with tuberculous pericarditis using echocardiography and fractal analysis, and to determine whether there ...Read morecb
Author:Ntsekhe, MpikoDate:2011Tuberculous (TB) pericarditis is associated with a mortality rate of 17-40% despite treatment with anti-tuberculosis drugs. The complications of TB pericarditis that confer mortality and morbidity are pericardial tamponade, effusive constrictive ...Read more
Author:de Villiers, Marthinus CoenraadDate:2019Background. Little is known about the current clinical profile and outcomes of patients with infective endocarditis (IE) in South Africa. Methods. We conducted a retrospective review of the records of patients admitted to Groote Schuur Hospital ...Read more
Author:Boloko, LindaDate: 2020Introduction: The impact of HIV on the one-month perioperative morbidity and mortality in patients undergoing cardiac surgery in sub-Saharan Africa (SSA) in the AntiRetroviral Therapy (ART) era is not known. Pre ART era data from South Africa ...Read more
Author:Isiguzo, Godsent ChichebemDate:2019Background
Randomised control trials (RCTs) are capital-intensive projects and demand substantial human and capital resources. Therefore, proper planning, precise research questions and adequate thoughts are required in areas such as ...Read more
Author:Cindi, ZinhleDate:2018Background: Warfarin is the most commonly used drug in the management of thromboembolic disease. However, there is a huge variability in the management of warfarin affecting the international normalized ratio (INR). Many genetic-association ...Read more
Author:Makambwa, EdsonDate:2019Warfarin, the most commonly prescribed anticoagulant, is principally metabolized by cytochrome P450 2C9 which functions by inhibiting the Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 ...Read more