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Browsing by Author "Ntsekhe, Mpiko"

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Achievement of secondary prevention goals 6 to 9 months after Acute Coronary Syndrome : a retrospective, cross-sectional analysis

Author: Griffiths, Bradley Paul Date: 2014 Study Rationale: Good evidence exists to support the use of secondary prevention medications (aspirin, HMG-CoA reductase inhibitors [statins], beta-blockers and angiotensin-converting enzyme inhibitors [ACEIs] or angiotensin receptor blockers ... Read more
Advancing global health through cardiovascular research, mentorship, and capacity building: in memoriam, professor Bongani Mayosi (1967–2018)

Author: Nachega, Jean B ; Ntsekhe, Mpiko ; Volmink, Jimmy ; Thabane, Lehana Date: 03 Oct 2018 We are deeply saddened by the passing of Professor Bongani Mayosi. Bongani was one of the inaugural board members of Pilot and Feasibility Studies. He contributed greatly to the design and conduct of pilot and feasibility studies in cardiovascular ... Read more
Cardio-thoracic ratio is stable, reproducible and has potential as a screening tool for HIV-1 related cardiac disorders in resource poor settings

Author: Esmail, Hanif ; Oni, Tolu ; Thienemann, Friedrich ; Omar-Davies, Nashreen ; Wilkinson, Robert J ; Ntsekhe, Mpiko Date: 2016 BACKGROUND: Cardiovascular disorders are common in HIV-1 infected persons in Africa and presentation is often insidious. Development of screening algorithms for cardiovascular disorders appropriate to a resource-constrained setting could ... Read more c b
Clinical characteristics and initial management of patients with tuberculous pericarditis in the HIV era: the Investigation of the Management of Pericarditis in Africa (IMPI Africa) registry

Author: Mayosi, Bongani ; Wiysonge, Charles ; Ntsekhe, Mpiko ; Volmink, Jimmy ; Gumedze, Freedom ; Maartens, Gary ; Aje, Akinyemi ; Thomas, Baby ; Thomas, Kandathil ; Awotedu, Abolade ; Thembela, Bongani ; Mntla, Phindile ; Maritz, Frans ; Blackett, Kathleen ; Nkouonlack, Date: 2006 BACKGROUND:The incidence of tuberculous pericarditis has increased in Africa as a result of the human immunodeficiency virus (HIV) epidemic. However, the effect of HIV co-infection on clinical features and prognosis in tuberculous pericarditis ... Read more c b
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-γ in a high burden setting: a prospective study

Author: Pandie, Shaheen ; Peter, Jonathan G ; Kerbelker, Zita S ; Meldau, Richard ; Theron, Grant ; Govender, Ureshnie ; Ntsekhe, Mpiko ; Dheda, Keertan ; Mayosi, Bongani M Date: 18 Jun 2014 Background: Tuberculous pericarditis (TBP) is associated with high morbidity and mortality, and is an important treatable cause of heart failure in developing countries. Tuberculous aetiology of pericarditis is difficult to diagnose promptly. ... Read more
Diagnostic utility of pericardial fluid pH in diagnosing infectious pericardial effusions among patients with moderate and large effusions undergoing pericardiocentesis at Groote Schuur Hospital: a subs-study of the IMPI trial

Author: Kiggundu, Brian Date: 2020 Diagnosis of infectious pericardial disease has been challenging in the developing world despite improvement of treatment modalities. The diagnostic utility of pH in diagnosing infectious pericardial fluid is unknown, yet this concept is well ... Read more
HIV infection is associated with a lower incidence of constriction in presumed tuberculous pericarditis: a prospective observational study

Author: Ntsekhe, Mpiko ; Wiysonge, Charles S ; Gumedze, Freedom ; Maartens, Gary ; Commerford, Patrick J ; Volmink, Jimmy A ; Mayosi, Bongani M Date: 2008 BACKGROUND: Pericardial constriction is a serious complication of tuberculous pericardial effusion that occurs in up to a quarter of patients despite anti-tuberculosis chemotherapy. The impact of human immunodeficiency virus (HIV) infection ... Read more c b
The investigation of the management of pericarditis in Africa (IMPI Africa) project : rationalé, design, baseline characteristics and mortality in a multinational registry of suspected tuberculous pericarditis

Author: Ntsekhe, Mpiko Date: 2006 Includes bibliographical references. Read more
Investigation of the management of tuberculous pericarditis (IMPI) registry : survival and outcomes sub-study

Author: Mubanga, Mwenya Date: 2012 Includes abstract. Includes bibliographical references. Read more
Mortality in patients treated for tuberculous pericarditis in sub-Saharan Africa.

Author: Mayosi, Bongani M ; Wiysonge, Charles Shey ; Ntsekhe, Mpiko ; Gumedze, Freedom ; Volmink Jimmy A ; Maartens, Gary ; Aje, Akinyemi ; Thomas, Baby M ; Thomas, Kandathil M ; Awotedu, Abolade A ; Bongani, Thembela ; Mntla, Phindile ; Maritz, Frans ; Blackett, Kathleen Ngu ; Nkouonlack, Duquesne C ; Burch, Vanessa C ; Rebe, Kevin ; Parrish, Andy ; Sliwa, Karen ; Vezi, Brian Z ; Alam, Nowshad ; Brown, Basil G ; Gould, Trevor ; Visser, Tim ; Magula, Nombulelo P ; Commerford, Patrick J Date: 2008 Tuberculous pericarditis is one of the most severe forms of extrapulmonary tuberculosis, causing death or disability in a substantial proportion of affected people.1,2 In Africa, the incidence of tuberculous pericarditis is rising as a result ... Read more
Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion

Author: Ntsekhe, Mpiko ; Matthews, Kerryn ; Syed, Faisal F ; Deffur, Armin ; Badri, Motasim ; Commerford, Patrick J ; Gersh, Bernard J ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Mayosi, Bongani M Date: 2013 BACKGROUND: Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on ... Read more c b
Quantification of echodensities in tuberculous pericardial effusion using fractal geometry: a proof of concept study

Author: Ntsekhe, Mpiko ; Mayosi, Bongani ; Gumbo, Tawanda Date: 2012 BACKGROUND:The purpose of this study was to quantify the heterogeneous distribution of echodensities in the pericardial fluid of patients with tuberculous pericarditis using echocardiography and fractal analysis, and to determine whether there ... Read more c b
Studies of effusive constrictive pericarditis

Author: Ntsekhe, Mpiko Date: 2011 Tuberculous (TB) pericarditis is associated with a mortality rate of 17-40% despite treatment with anti-tuberculosis drugs. The complications of TB pericarditis that confer mortality and morbidity are pericardial tamponade, effusive constrictive ... Read more
The changing landscape of infective endocarditis in South Africa

Author: de Villiers, Marthinus Coenraad Date: 2019 Background. Little is known about the current clinical profile and outcomes of patients with infective endocarditis (IE) in South Africa. Methods. We conducted a retrospective review of the records of patients admitted to Groote Schuur Hospital ... Read more
The impact of HIV on 30-day survival amongst patients undergoing cardiac surgery at Groote Schuur Hospital in the ART era

Author: Boloko, Linda Date: 2020 Introduction: The impact of HIV on the one-month perioperative morbidity and mortality in patients undergoing cardiac surgery in sub-Saharan Africa (SSA) in the AntiRetroviral Therapy (ART) era is not known. Pre ART era data from South Africa ... Read more
The role and essence of pilot trials and subgroup analysis in cardiovascular research: the IMPI trial experience

Author: Isiguzo, Godsent Chichebem Date: 2019 Background Randomised control trials (RCTs) are capital-intensive projects and demand substantial human and capital resources. Therefore, proper planning, precise research questions and adequate thoughts are required in areas such as ... Read more
The role of genetic variation in VKORC1 and GGCX on warfarin response in a South African population

Author: Cindi, Zinhle Date: 2018 Background: Warfarin is the most commonly used drug in the management of thromboembolic disease. However, there is a huge variability in the management of warfarin affecting the international normalized ratio (INR). Many genetic-association ... Read more
The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1

Author: Makambwa, Edson Date: 2019 Warfarin, the most commonly prescribed anticoagulant, is principally metabolized by cytochrome P450 2C9 which functions by inhibiting the Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 ... Read more
The tetrapeptide Ac-SDKP and angiotensin converting enzyme in tuberculous pericarditis and fibrosis

Author: Ramasamy, Vinasha Date: 2020 Tuberculous pericarditis is an extra pulmonary form of tuberculosis (TB) which leads to a lifethreatening form of pericardial fibrosis in up to 25% of patients despite anti tuberculous therapy. The mechanisms leading to the fibrotic phenotype ... Read more

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Browsing by Author "Ntsekhe, Mpiko"

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