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Browsing by Author "Norman, Jennifer"

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Detectable HIV-1 in semen in individuals with very low blood viral loads

Author: Kariuki, Samuel M ; Selhorst, Philippe ; Norman, Jennifer ; Cohen, Karen ; Rebe, Kevin ; Williamson, Carolyn ; Dorfman, Jeffrey R Date: 05 Mar 2020 Abstract Background Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 ... Read more
Determination of Rifapentine and 25-O-desacetyl Rifapentine from 100 µl human breastmilk by LC-MS/MS using protein precipitation and solid phase extraction

Author: Mkhize, Buyisile Date: 2019 There is currently no information available on the transfer of the second-line anti-TB drug, rifapentine and its metabolite, into breastmilk. The subsequent implications to the breastfed infant, as well as consequences of long-term exposure ... Read more
Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids

Author: Lombard, Marli ; N'Da, David ; Tran Van Ba, Christophe ; Wein, Sharon ; Norman, Jennifer ; Wiesner, Lubbe ; Vial, Henri Date: 2013 BACKGROUND:Because Plasmodium falciparum displays increase tolerance against the recommended artemisinin combination therapies (ACT), new classes of anti-malarial drugs are urgently required. Previously synthesized artemisinin-aminoquinoline ... Read more c b
Simultaneous quantification of first-line anti-tuberculosis drugs and metabolites in human plasma

Author: Mazanhanga, Marian Tafadzwa Date: 2019 Tuberculosis (TB) currently kills more people than any other infectious disease worldwide, the highest burden being in Africa and Asia (1). Therapy recommended for drug sensitive TB consists of a cocktail of isoniazid (INH), rifampicin (RIF), ... Read more

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