OpenUCT Home
→
Browsing by Author

Browsing by Author "Ngandu, Nobubelo"

Now showing items 1-3 of 3

Evidence of HIV-1 adaptation to host HLA alleles following chimp-to-human transmission

Author: Ngandu, Nobubelo ; Seoighe, Cathal ; Scheffler, Konrad Date: 2009 BACKGROUND:The cytotoxic T-lymphocyte immune response is important in controlling HIV-1 replication in infected humans. In this immune pathway, viral peptides within infected cells are presented to T-lymphocytes by the polymorphic human ... Read more c b
Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences

Author: Ngandu, Nobubelo ; Scheffler, Konrad ; Moore, Penny ; Woodman, Zenda ; Martin, Darren ; Seoighe, Cathal Date: 2008 BACKGROUND: Positive selection pressure acting on protein-coding sequences is usually inferred when the rate of nonsynonymous substitution is greater than the synonymous rate. However, purifying selection acting directly on the nucleotide ... Read more c b
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

Author: Lacerda, Miguel ; Moore, Penny ; Ngandu, Nobubelo ; Seaman, Michael ; Gray, Elin ; Murrell, Ben ; Krishnamoorthy, Mohan ; Nonyane, Molati ; Madiga, Maphuti ; Wibmer, Constantinos ; Sheward, Daniel ; Bailer, Robert ; Gao, Hongmei ; Greene, Kelli ; Karim, Salim S ; M Date: 2013 BACKGROUND:Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. METHODS: We have developed a computational approach that can ... Read more c b

Now showing items 1-3 of 3

Browse

All of OpenUCT

Browsing by Author "Ngandu, Nobubelo"

Browsing by Author "Ngandu, Nobubelo"

Browse

All of OpenUCT