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Browsing by Author "Moore, Penny L"

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Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV

Author: Chapman, Ros ; van Diepen, Michiel ; Douglass, Nicola ; Galant, Shireen ; Jaffer, Mohamed ; Margolin, Emmanuel ; Ximba, Phindile ; Hermanus, Tandile ; Moore, Penny L ; Williamson, Anna-Lise Date: 05 Nov 2021 The modest protective effects of the RV144 HIV-1 vaccine trial have prompted the further exploration of improved poxvirus vector systems that can yield better immune responses and protection. In this study, a recombinant lumpy skin disease ... Read more c b
Case report: mechanisms of HIV elite control in two African women

Author: Moosa, Yumna ; Tanko, Ramla F ; Ramsuran, Veron ; Singh, Ravesh ; Madzivhandila, Mashudu ; Yende-Zuma, Nonhlanhla ; Abrahams, Melissa-Rose ; Selhorst, Philippe ; Gounder, Kamini ; Moore, Penny L ; Williamson, Carolyn ; Abdool Karim, Salim S ; Garrett, Nigel J ; Burgers, Wendy A Date: 25 Jan 2018 Background: The majority of people living with HIV require antiretroviral therapy (ART) for controlling viral replication, however there are rare HIV controllers who spontaneously and durably control HIV in the absence of treatment. Understanding ... Read more c b
Chinks in the armor of the HIV-1 Envelope glycan shield: implications for immune escape from anti-glycan broadly neutralizing antibodies

Author: Moyo, Thandeka ; Ferreira, Roux-cil ; Davids, Reyaaz ; Sonday, Zarinah ; Moore, Penny L ; Travers, Simon A ; Wood, Natasha T ; Dorfman, Jeffrey Robert Date: 15 Jan 2017 Glycans on HIV-1 Envelope serve multiple functions including blocking epitopes from antibodies. We show that removal of glycan 301, a major target of anti-V3/glycan antibodies, has substantially different effects in two viruses. While glycan ... Read more
Features of recently transmitted HIV-1 clade C viruses that impact antibody recognition: implications for active and passive immunization

Author: Rademeyer, Cecilia ; Korber, Bette ; Seaman, Michael S ; Giorgi, Elena E ; Thebus, Ruwayhida ; Robles, Alexander ; Sheward, Daniel J ; Wagh, Kshitij ; Garrity, Jetta ; Carey, Brittany R ; Gao, Hongmei ; Greene, Kelli M ; Tang, Haili ; Bandawe, Gama P ; Marais, Jinny C ; Diphoko, Thabo E ; Hraber, Peter ; Tumba, Nancy ; Moore, Penny L ; Gray, Glenda E ; Kublin, James ; McElrath, M Juliana ; Vermeulen, Marion ; Middelkoop, Keren ; Bekker, Linda-Gail ; Hoelscher, Michael ; Maboko, Leonard ; Makhema, Joseph ; Robb, Merlin L ; Karim, Salim Abdool ; Karim, Quarraisha Abdool ; Kim, Jerome H ; Hahn, Beatrice H ; Gao, Feng ; Swanstrom, Ronald ; Morris, Lynn ; Montefiori, David C ; Williamson, Carolyn Date: 2016 Author Summary: Vaccine and passive immunization prophylactic trials that rely on antibody-mediated protection are planned for HIV-1 clade C epidemic regions of southern Africa, which have amongst the highest HIV-1 incidences globally. This ... Read more c b
Limited neutralizing antibody specificities drive neutralization escape in early HIV-1 subtype C infection

Author: Moore, Penny L ; Ranchobe, Nthabeleng ; Lambson, Bronwen E ; Gray, Elin S ; Cave, Eleanor ; Abrahams, Melissa-Rose ; Bandawe, Gama ; Mlisana, Koleka ; Karim, Salim S Abdool ; Williamson, Carolyn Date: 2009 Author Summary Most HIV-1 infected individuals develop neutralizing antibodies against their own virus, termed an autologous neutralizing response. It is known that this response exerts pressure on the envelope of HIV, the target of such ... Read more c b
Neutralizing antibody responses in HIV dual infection: lessons for vaccine design

Author: Sheward, Daniel James Date: 2022 The development of a safe, effective prophylactic HIV vaccine remains a major global health priority. Stabilized, soluble trimers that mimic the native functional HIV trimer have been developed that elicit strain-specific neutralizing HIV ... Read more
Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes

Author: Wibmer, Constantinos Kurt ; Bhiman, Jinal N ; Gray, Elin S ; Tumba, Nancy ; Karim, Salim S Abdool ; Williamson, Carolyn ; Morris, Lynn ; Moore, Penny L Date: 2013 Identifying the targets of broadly neutralizing antibodies to HIV-1 and understanding how these antibodies develop remain important goals in the quest to rationally develop an HIV-1 vaccine. We previously identified a participant in the CAPRISA ... Read more c b

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Browsing by Author "Moore, Penny L"

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