Browsing by Author "Moore, Penny"

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Extensive purifying selection acting on synonymous sites in HIV-1 Group M sequences

Author: Ngandu, Nobubelo ; Scheffler, Konrad ; Moore, Penny ; Woodman, Zenda ; Martin, Darren ; Seoighe, Cathal Date: 2008 BACKGROUND: Positive selection pressure acting on protein-coding sequences is usually inferred when the rate of nonsynonymous substitution is greater than the synonymous rate. However, purifying selection acting directly on the nucleotide ... Read more c b
Identification of broadly neutralizing antibody epitopes in the HIV-1 envelope glycoprotein using evolutionary models

Author: Lacerda, Miguel ; Moore, Penny ; Ngandu, Nobubelo ; Seaman, Michael ; Gray, Elin ; Murrell, Ben ; Krishnamoorthy, Mohan ; Nonyane, Molati ; Madiga, Maphuti ; Wibmer, Constantinos ; Sheward, Daniel ; Bailer, Robert ; Gao, Hongmei ; Greene, Kelli ; Karim, Salim S ; M Date: 2013 BACKGROUND:Identification of the epitopes targeted by antibodies that can neutralize diverse HIV-1 strains can provide important clues for the design of a preventative vaccine. METHODS: We have developed a computational approach that can ... Read more c b

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