OpenUCT Home
→
Browsing by Author

Browsing by Author "Mazandu, Gaston K"

Now showing items 1-8 of 8

A post-gene silencing bioinformatics protocol for plant-defence gene validation and underlying process identification: case study of the Arabidopsis thaliana NPR1

Author: Yocgo, Rosita E ; Geza, Ephifania ; Chimusa, Emile R ; Mazandu, Gaston K Date: 23 Nov 2017 Background: Advances in forward and reverse genetic techniques have enabled the discovery and identification of several plant defence genes based on quantifiable disease phenotypes in mutant populations. Existing models for testing the effect ... Read more
ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations

Author: Chimusa, Emile R ; Mbiyavanga, Mamana ; Mazandu, Gaston K ; Mulder, Nicola J Date: 27 Despite numerous successful Genome-wide Association Studies (GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may miss disease genes with weak genetic effects or strong epistatic effects due to the single-marker ... Read more
Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania

Author: Nkya, Siana ; Mwita, Liberata ; Mgaya, Josephine ; Kumburu, Happiness ; van Zwetselaar, Marco ; Menzel, Stephan ; Mazandu, Gaston K ; Sangeda, Raphael ; Chimusa, Emile ; Makani, Julie Date: 05 Jun 2020 Background Sickle cell disease (SCD) is a blood disorder caused by a point mutation on the beta globin gene resulting in the synthesis of abnormal hemoglobin. Fetal hemoglobin (HbF) reduces disease severity, but the levels vary from one ... Read more c b
Information content-based gene ontology functional similarity measures: which one to use for a given biological data type?

Author: Mazandu, Gaston K ; Mulder, Nicola J Date: 2014 The current increase in Gene Ontology (GO) annotations of proteins in the existing genome databases and their use in different analyses have fostered the improvement of several biomedical and biological applications. To integrate this functional ... Read more c b
Investigating local ancestry inference models in mixed ancestry individual genomes

Author: Geza, Ephifania Date: 2022 Owing to historical events including the slave trade, agricultural interests, colonialism, and political and/or economical instability, most modern humans are a mosaic of segments originating from different populations. They result from the ... Read more
Predicting and analyzing interactions between Mycobacterium tuberculosis and its human host

Author: Rapanoel, Holifidy A ; Mazandu, Gaston K ; Mulder, Nicola J Date: 2013 The outcome of infection by Mycobacterium tuberculosis (Mtb) depends greatly on how the host responds to the bacteria and how the bacteria manipulates the host, which is facilitated by protein-protein interactions. Thus, to understand this ... Read more c b
Scoring protein relationships in functional interaction networks predicted from sequence data

Author: Mazandu, Gaston K ; Mulder, Nicola J Date: 2011 The abundance of diverse biological data from various sources constitutes a rich source of knowledge, which has the power to advance our understanding of organisms. This requires computational methods in order to integrate and exploit these ... Read more c b
A web-based protein interaction network visualizer

Author: Salazar, Gustavo A ; Meintjes, Ayton ; Mazandu, Gaston K ; Rapanoël, Holifidy A ; Akinola, Richard O ; Mulder, Nicola J Date: 06 May 2014 Abstract Background Interaction between proteins is one of the most important mechanisms in the execution of cellular functions. The study of these interactions has provided insight into the ... Read more c b

Now showing items 1-8 of 8

Browse

All of OpenUCT

Browsing by Author "Mazandu, Gaston K"

Browsing by Author "Mazandu, Gaston K"

Browse

All of OpenUCT