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Browsing by Author "Mahomed, Hassan"

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The candidate TB vaccine, MVA85A, induces highly durable Th1 responses

Author: Tameris, Michele ; Geldenhuys, Hennie ; Luabeya, Angelique KanyKany ; Smit, Erica ; Hughes, Jane E ; Vermaak, Samantha ; Hanekom, Willem A ; Hatherill, Mark ; Mahomed, Hassan ; McShane, Helen ; Scriba,Thomas J Date: 2014 BACKGROUND: Vaccination against tuberculosis (TB) should provide long-term protective immunity against Mycobacterium tuberculosis ( M.tb ). The current TB vaccine, Bacille Calmette-Guerin (BCG), protects against disseminated childhood TB, but ... Read more c b
Childhood mortality in the Boland Overberg region

Author: Moyo, Sizulu Date: 2007 The aim of this thesis is to characterise the profile of infant, childhood and adolescent mortality in three adjancent district municipalities in the Boland region of the Western Cape Province of South Africa. Read more
Comparison of mantoux and tine tuberculin skin tests in BCG-vaccinated children investigated for tuberculosis

Author: Pan, Wenli ; Matizirofa, Lyness ; Workman, Lesley ; Hawkridge, Tony ; Hanekom, Willem ; Mahomed, Hassan ; Hussey, Gregory ; Hatherill, Mark Date: 2009 Background: Tuberculin skin tests (TSTs) are long-established screening methods for tuberculosis (TB). We aimed to compare agreement between the intradermal Mantoux and multipuncture percutaneous Tine methods and to quantify risk factors for ... Read more c b
COVID-19 and the Gaping Wounds of South Africa’s Suboptimal Immunisation Coverage: An Implementation Research Imperative for Assessing and Addressing Missed Opportunities for Vaccination

Author: Nnaji, Chukwudi A ; Wiysonge, Charles S ; Lesosky, Maia ; Mahomed, Hassan ; Ndwandwe, Duduzile Date: 23 Jun 2021 Despite South Africa’s substantial investments in and efforts at ensuring universal access to immunisation services, progress has stalled and remains suboptimal across provinces and districts. An additional challenge is posed by the ongoing ... Read more c b
Evaluation of Xpert® MTB/RIF assay in induced sputum and gastric lavage samples from young children with suspected tuberculosis from the MVA85A TB vaccine trial

Author: Bunyasi, Erick Wekesa ; Tameris, Michele ; Geldenhuys, Hennie ; Schmidt, Bey-Marrie ; Luabeya, Angelique Kany Kany ; Mulenga, Humphrey ; Scriba, Thomas J ; Hanekom, Willem A ; Mahomed, Hassan ; McShane, Helen Date: 2015 Objective Diagnosis of childhood tuberculosis is limited by the paucibacillary respiratory samples obtained from young children with pulmonary disease. We aimed to compare accuracy of the Xpert ® MTB/RIF assay, an automated nucleic acid ... Read more c b
The incidence of tuberculosis in adolescents in the context of proposed TB vaccine trials

Author: Mahomed, Hassan Date: 2013 [Background] Tuberculosis (TB) is a significant global health problem and the development of new TB vaccines is one strategy proposed to address this scourge. Adolescents are a potential target group for new TB vaccines. Limited data are ... Read more
Isolation of Non-Tuberculous Mycobacteria in Children Investigated for Pulmonary Tuberculosis

Author: Hatherill, Mark ; Hawkridge, Tony ; Whitelaw, Andrew ; Tameris, Michele ; Mahomed, Hassan ; Moyo, Sizulu ; Hanekom, Willem ; Hussey, Gregory Date: 2006 Objective To evaluate the frequency and clinical significance of non-tuberculous mycobacteria (NTM) isolates among children investigated for pulmonary tuberculosis in a rural South African community. METHODS: Children were investigated for ... Read more c b
Missed Opportunities for Vaccination and Associated Factors among Children Attending Primary Health Care Facilities in Cape Town, South Africa: A Pre-Intervention Multilevel Analysis

Author: Nnaji, Chukwudi A ; Wiysonge, Charles S ; Adamu, Abdu A ; Lesosky, Maia ; Mahomed, Hassan ; Ndwandwe, Duduzile Date: 16 May 2022 Despite the substantial efforts at ensuring universal access to routine immunisation services among children in South Africa, major gaps in immunisation coverage remain. This study assessed the magnitude of missed opportunities for vaccination ... Read more c b
The predictive value of a QuantiFERON conversion in the development of active tuberculosis disease in adolescents

Author: Machingaidze, Shingai Date: 2011 This study is an extension of a prospective epidemiological study of TB disease and infection in adolescents in the Worcester and surrounding areas in the Western Cape carried out from 2005 to 2009, in which 6363 participants were enrolled ... Read more
TB incidence in an adolescent cohort in South Africa

Author: Mahomed, Hassan ; Ehrlich, Rodney ; Hawkridge, Tony ; Hatherill, Mark ; Geiter, Lawrence ; Kafaar, Fazlin ; Abrahams, Deborah Ann ; Mulenga, Humphrey ; Tameris, Michele ; Geldenhuys, Hennie Date: 2013 BACKGROUND: Tuberculosis (TB) is a major public health problem globally. Little is known about TB incidence in adolescents who are a proposed target group for new TB vaccines. We conducted a study to determine the TB incidence rates and risk ... Read more c b
The tuberculin skin test versus QuantiFERON TB Gold® in predicting tuberculosis disease in an adolescent cohort study in South Africa

Author: Mahomed, Hassan ; Hawkridge, Tony ; Verver, Suzanne ; Abrahams, Deborah ; Geiter, Lawrence ; Hatherill, Mark ; Ehrlich, Rodney ; Hanekom, Willem A ; Hussey, Gregory D Date: 2011 Setting This study was conducted in a high tuberculosis (TB) burden area in Worcester, South Africa, with a notified all TB incidence rate of 1,400/100,000. Main Objective To compare the predictive value of a baseline tuberculin skin test ... Read more c b

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