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Browsing by Author "Leeto, Mosiuoa"

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IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections

Author: Marillier, Reece ; Michels, Chesney ; Smith, Elizabeth ; Fick, Lizette ; Leeto, Mosiuoa ; Dewals, Benjamin ; Horsnell, William ; Brombacher, Frank Date: 2008 BACKGROUND: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is ... Read more c b
IL-4Rα-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness

Author: Dewals, Benjamin G ; Marillier, Reece G ; Hoving, Jennifer C ; Leeto, Mosiuoa ; Schwegmann, Anita ; Brombacher, Frank Date: 2010 IL-4Rα-dependent responses are essential for granuloma formation and host survival during acute schistosomiasis. Previously, we demonstrated that mice deficient for macrophage-specific IL-4Rα (LysMcreIl4ra−/lox) developed increased hepatotoxicity ... Read more c b
Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells

Author: Cook, Peter C ; Aynsley, Sarah A ; Turner, Joseph D ; Jenkins, Gavin R ; Van Rooijen, Nico ; Leeto, Mosiuoa ; Brombacher, Frank ; Mountford, Adrian P Date: 2011 Infection of the mammalian host by schistosome larvae occurs via the skin, although nothing is known about the development of immune responses to multiple exposures of schistosome larvae, and/or their excretory/secretory (E/S) products. Here, ... Read more c b
The role of IL-4Ra during acute schistosomiasis

Author: Leeto, Mosiuoa Date: 2006 During an infection with Schistosoma mansoni, immunopathology is associated with a dominant TH-2 type cytokine expression, tissue cosinophilia and high levels of serum immunoglobulin E. It is postulated that in addition to egg specific CD4+T ... Read more

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Browsing by Author "Leeto, Mosiuoa"

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