Author:Lawn, Stephen; Myer, Landon; Bekker, Linda-Gail; Wood, RobinDate:2006BACKGROUND:Patients accessing antiretroviral treatment (ART) programmes in sub-Saharan Africa frequently have very advanced immunodeficiency. Previous data suggest that such patients may have diminished capacity for CD4 cell count recovery. ...Read morecb
Author:Maynard-Smith, Laura; Larke, Natasha; Peters, Jurgens; Lawn, StephenDate:2014BACKGROUND:Although the evidence base regarding the use of the Xpert MTB/RIF assay for diagnosis of pulmonary tuberculosis (TB) when testing respiratory samples is well established, the evidence base for its diagnostic accuracy for extrapulmonary ...Read morecb
Author:Lawn, Stephen; Kerkhoff, Andrew; Vogt, Monica; Wood, RobinDate:2013BACKGROUND: Reducing mortality from HIV-associated tuberculosis (TB) requires diagnostic tools that are rapid and have high sensitivity among patients with poor prognosis. We determined the relationship between disease severity and the ...Read morecb
Author:Nglazi, Mweete; Kaplan, Richard; Wood, Robin; Bekker, Linda-Gail; Lawn, StephenDate:2010BACKGROUND:High rates of loss to follow-up (LTFU) are undermining rapidly expanding antiretroviral treatment (ART) services in sub-Saharan Africa. The intelligent dispensing of ART (iDART) is an open-source electronic pharmacy system that ...Read morecb
Author:Lawn, Stephen; Meintjes, Graeme; McIlleron, Helen; Harries, Anthony; Wood, RobinDate:2013The HIV-associated tuberculosis (TB) epidemic remains a huge challenge to public health in resource-limited settings. Reducing the nearly 0.5 million deaths that result each year has been identified as a key priority. Major progress has been ...Read morecb
Author:Lawn, Stephen; Myer, Landon; Bangani, Nonzwakazi; Vogt, Monica; Wood, RobinDate:2007Background: Serum concentrations of soluble urokinase-type plasminogen activator receptor (suPAR) have a strong independent association with HIV-1-related mortality. The practical utility of plasma suPAR in assessing short-term all-cause ...Read morecb
Author:Lawn, StephenDate:2012Detection of Mycobacterium tuberculosis antigens in urine is attractive as a potential means of diagnosing tuberculosis (TB) regardless of the anatomical site of disease. The most promising candidate antigen is the cell wall lipopolysaccharide ...Read morecb
Author:Pathai, Sophia; Deshpande, Alaka; Gilbert, Clare; Lawn, StephenDate:2009BACKGROUND: The ocular manifestations of HIV may lead to visual impairment or blindness. In India, patients typically initiate antiretroviral treatment (ART) with low CD4 cell counts when the risk of ocular complications may be high. The ...Read morecb
Author:Kerkhoff, Andrew; Gupta, Ankur; Samandari, Taraz; Lawn, StephenDate:2013BACKGROUND:A positive tuberculin skin test (TST) is often defined by skin induration of [greater than or equal to]10mm in people who are HIV-seronegative. However, to increase sensitivity for detection of Mycobacterium tuberculosis infection ...Read morecb
Author:Lawn, StephenDate:2013In this video Q&A, we talk to Dr Stephen Lawn about the point-of-care LAM test for HIV-associated TB, which has the potential to save lives by improving rapid diagnosis and treatment.Read morecb