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Browsing by Author "Kirstein, Frank"

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IL-4Rα-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection

Author: Horsnell, William G C ; Darby, Matthew G ; Hoving, Jennifer C ; Nieuwenhuizen, Natalie ; McSorley, Henry J ; Ndlovu, Hlumani ; Bobat, Saeeda ; Kimberg, Matti ; Kirstein, Frank ; Cutler, Anthony J Date: 2013 In this study, B cell function in protective TH2 immunity against N. brasiliensis infection was investigated. Protection against secondary infection depended on IL-4Rα and IL-13; but not IL-4. Protection did not associate with parasite specific ... Read more c b
Investigations of immune responses in different mouse models of allergic asthma

Author: Kirstein, Frank Date: 2008 Read more
Microbial ligand costimulation drives neutrophilic steroid-refractory asthma

Author: Hadebe, Sabelo ; Kirstein, Frank ; Fierens, Kaat ; Chen, Kong ; Drummond, Rebecca A ; Vautier, Simon ; Sajaniemi, Sara ; Murray, Graeme ; Williams, David L ; Redelinghuys, Pierre ; Reinhart, Todd A ; Junecko, Beth A Fallert ; Kolls, Jay K ; Lambrecht, Bart N ; Brombacher, Frank ; Brown, Gordon D Date: 2015 Asthma is a heterogeneous disease whose etiology is poorly understood but is likely to involve innate responses to inhaled microbial components that are found in allergens. The influence of these components on pulmonary inflammation has been ... Read more c b
The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation

Author: Khumalo, Jermaine Date: 2019 Allergic asthma is a chronic inflammatory airway disease driven predominantly by a TH2 immune response to environmental allergens. The asthma pathology is predominantly elicited by IL-4 and IL-13 signalling via IL-4Rα-signalling which is ... Read more
β-Glucan exacerbates allergic airway responses to house dust mite allergen

Author: Hadebe, Sabelo ; Kirstein, Frank ; Fierens, Kaat ; Redelinghuys, Pierre ; Murray, Graeme I ; Williams, David L ; Lambrecht, Bart N ; Brombacher, Frank ; Brown, Gordon D Date: 2016 β-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. β-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are ... Read more c b

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Browsing by Author "Kirstein, Frank"

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