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Browsing by Author "Khati, Makobetsa"

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An analysis of alcohol use and possible confounding risk factors for risky sexual behaviour amongst women in the rural Western Cape and urban Gauteng provinces

Author: Khati, Makobetsa Date: 2013 The general aim of this thesis is therefore to analyse alcohol consumption variables and possible confounding risk factors associated with risky sexual behaviour amongst women in the urban city of Tshwane in Gauteng and the rural Western Cape ... Read more
The development of aptamer-based probes for the detection of TB antigens ESAT-6.CFP-10 potential TB diagnostic tools

Author: Maserumule, Matsopiane Charlotte Date: 2013 Lack of point-of-care (PoC) diagnostic tools for TB hinders control of the disease, particularly in resource-limited, high HIV and TB prevalence countries. Therefore, there is a need for simple, rapid, accurate, and affordable PoC diagnostics ... Read more
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria

Author: Ngubane, Nqobile A C ; Gresh, Lionel ; Ioerger, Thomas R ; Sacchettini, James C ; Zhang, Yanjia J ; Rubin, Eric J ; Pym, Alexander ; Khati, Makobetsa Date: 2013 Bacterial cell wall components have been previously used as infection biomarkers detectable by antibodies. However, it is possible that the surface of the Mycobacterium tuberculosis ( M. tb ), the causative agent of tuberculosis (TB), also ... Read more c b
HIV-1 subtype C unproductively infects human cardiomyocytes in vitro and induces apoptosis mitigated by an anti-gp120 aptamer

Author: de Campos, Walter R Lopes ; Chirwa, Nthato ; London, Grace ; Rotherham, Lia S ; Morris, Lynn ; Mayosi, Bongani M ; Khati, Makobetsa Date: 2014 HIV-associated cardiomyopathy (HIVCM) is of clinical concern in developing countries because of a high HIV-1 prevalence, especially subtype C, and limited access to highly active antiretroviral therapy (HAART). For these reasons, we investigated ... Read more c b
A modeled structure of an aptamer-gp120 complex provides insight into the mechanism of HIV-1 neutralization

Author: Joubert, Marisa K ; Kinsley, Nichole ; Capovilla, Alexio ; Sewell, B Trevor ; Jaffer, Mohamed A ; Khati, Makobetsa Date: 2010 The HIV-1 envelope glycoprotein, gp120, is a key target for a class of drugs called entry inhibitors. Here we used molecular modeling to construct a three-dimensional model of an anti-gp120 RNA aptamer, B40t77, alone and in complex with gp120. ... Read more
Selection and application of ssDNA aptamers to detect active TB from sputum samples

Author: Rotherham, Lia S ; Maserumule, Charlotte ; Dheda, Keertan ; Theron, Jacques ; Khati, Makobetsa Date: 2012 BACKGROUND: Despite the enormous global burden of tuberculosis (TB), conventional approaches to diagnosis continue to rely on tests that have major drawbacks. The improvement of TB diagnostics relies, not only on good biomarkers, but also ... Read more c b

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Browsing by Author "Khati, Makobetsa"

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