Author:Nyangahu, Donald DDate:2017Maternal microbiota during pregnancy, as well as maternal disease state, may impact offspring gut bacterial colonisation. Here, we explore the impact of maternal antibiotics during gestation and/or nursing on offspring gut microbiota. Further, ...Read more
Author:Jaspan, Heather B; Huang, Lyen C; Cotton, Mark F; Whitelaw, Andrew; Myer, LandonDate:2008BACKGROUND: Serious bacterial infections are a major source of morbidity and mortality in HIV-infected children. The spectrum of disease is wide, and responsible organisms vary according to setting. The use of antibiotic prophylaxis and the ...Read morecb
Author:Nundalall, TrishanaDate:2017Introduction: Vaccination is one of the most efficient ways to prevent infectious diseases, however due to the naivety and regulation of immunity found in infants, induction of vaccine-mediated immunity is challenging. Respiratory and diarrheal ...Read more
Author:Kidzeru, Elvis BanboyeDate:2013Immunization against vaccine-preventable infections is essential to reducing childhood morbidity and mortality. The immaturity and tolerogenicity of the immune system of infants renders them susceptible to infectious diseases and makes induction ...Read more
Author:Kidzeru, Elvis BanboyeDate:2016BACKGROUND: Each year over 4 million infants die from infections, of which many are vaccinepreventable. Young infants respond poorly to vaccines, but the basis of reduced immunity is controversial. We hypothesized that myeloid-derived suppressor ...Read more
Author:Huang, Lyen C; Myer, Landon; Jaspan, Heather BDate:2008BACKGROUND:Mortality among HIV-infected children in developing countries remains high after serious bacterial infections despite the use of antibiotics. Intravenous immunoglobulin (IVIG) has been used as an adjuvant therapy to treat these ...Read morecb
Author:Breetzke, Aerin OliviaDate:2017Young, reproductive-aged women are at highest risk of acquiring human-immunodeficiency virus (HIV). The Women's Initiative in Sexual Health (WISH) study was designed to investigate potential biological reasons for this high risk in HIV negative, ...Read more