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Browsing by Author "Jaspan, Heather B"

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Alterations in preconception, antenatal, and postnatal maternal gut microbiota influence offspring intestinal microbiota and immunity

Author: Nyangahu, Donald D Date: 2017 Maternal microbiota during pregnancy, as well as maternal disease state, may impact offspring gut bacterial colonisation. Here, we explore the impact of maternal antibiotics during gestation and/or nursing on offspring gut microbiota. Further, ... Read more
Bacterial disease and antimicrobial susceptibility patterns in HIV-infected, hospitalized children: a retrospective cohort study

Author: Jaspan, Heather B ; Huang, Lyen C ; Cotton, Mark F ; Whitelaw, Andrew ; Myer, Landon Date: 2008 BACKGROUND: Serious bacterial infections are a major source of morbidity and mortality in HIV-infected children. The spectrum of disease is wide, and responsible organisms vary according to setting. The use of antibiotic prophylaxis and the ... Read more c b
CD4 and CD8 T-cell responses to acellular pertussis and rotavirus vaccination in breast-fed HIV exposed, uninfected infants

Author: Nundalall, Trishana Date: 2017 Introduction: Vaccination is one of the most efficient ways to prevent infectious diseases, however due to the naivety and regulation of immunity found in infants, induction of vaccine-mediated immunity is challenging. Respiratory and diarrheal ... Read more
Correction to: Microbial function and genital inflammation in young South African women at high risk of HIV infection

Author: Alisoltani, Arghavan ; Manhanzva, Monalisa T ; Potgieter, Matthys ; Balle, Christina ; Bell, Liam ; Ross, Elizabeth ; Iranzadeh, Arash ; du Plessis, Michelle ; Radzey, Nina ; McDonald, Zac ; Calder, Bridget ; Allali, Imane ; Mulder, Nicola ; Dabee, Smritee ; Barnabas, Shaun ; Gamieldien, Hoyam ; Godzik, Adam ; Blackburn, Jonathan M ; Tabb, David L ; Bekker, Linda-Gail ; Jaspan, Heather B ; Passmore, Jo-Ann S ; Masson, Lindi Date: 09 Mar 2022 Correction to: Microbiome 8, 165 (2020) https://doi.org/10.1186/s40168-020-00932-8 Read more c b
Disruption of maternal gut microbiota during gestation alters offspring microbiota and immunity

Author: Nyangahu, Donald D ; Lennard, Katie S ; Brown, Bryan P ; Darby, Matthew G ; Wendoh, Jerome M ; Havyarimana, Enock ; Smith, Peter ; Butcher, James ; Stintzi, Alain ; Mulder, Nicola ; Horsnell, William ; Jaspan, Heather B Date: 07 Jul 2018 Background: Early life microbiota is an important determinant of immune and metabolic development and may have lasting consequences. The maternal gut microbiota during pregnancy or breastfeeding is important for defining infant gut microbiota. ... Read more
The effect of HIV-exposure on immune responses to expanded programme on immunization vaccines and antigens

Author: Kidzeru, Elvis Banboye Date: 2013 Immunization against vaccine-preventable infections is essential to reducing childhood morbidity and mortality. The immaturity and tolerogenicity of the immune system of infants renders them susceptible to infectious diseases and makes induction ... Read more
Effects of delayed BCG vaccination on cellular immune responses in HIV-exposed infants

Author: Tchakoute, Christophe Toukam Date: 2014 Includes abstract. Includes bibliographical references. Read more
The impact of myeloid derived suppressor cells on vaccine immunogenicity in South African HIV-infected and uninfected mothers and their infants

Author: Kidzeru, Elvis Banboye Date: 2016 BACKGROUND: Each year over 4 million infants die from infections, of which many are vaccinepreventable. Young infants respond poorly to vaccines, but the basis of reduced immunity is controversial. We hypothesized that myeloid-derived suppressor ... Read more
In Silico Characterisation of Putative Prophages in Lactobacillaceae Used in Probiotics for Vaginal Health

Author: Happel, Anna-Ursula ; Kullin, Brian R ; Gamieldien, Hoyam ; Jaspan, Heather B ; Varsani, Arvind ; Martin, Darren ; Passmore, Jo-Ann S ; Froissart, Rémy Date: 20 Jan 2022 While live biotherapeutics offer a promising approach to optimizing vaginal microbiota, the presence of functional prophages within introduced Lactobacillaceae strains could impact their safety and efficacy. We evaluated the presence of ... Read more c b
Intra-and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials

Author: Zembe, Lycias ; Burgers, Wendy A ; Jaspan, Heather B ; Bekker, Linda-Gail ; Bredell, Helba ; Stevens, Gwynneth ; Gilmour, Jill ; Cox, Josephine H ; Fast, Patricia ; Hayes, Peter Date: 2011 The genetic diversity of HIV-1 across the globe is a major challenge for developing an HIV vaccine. To facilitate immunogen design, it is important to characterize clusters of commonly targeted T-cell epitopes across different HIV clades. To ... Read more c b
Microbial function and genital inflammation in young South African women at high risk of HIV infection

Author: Alisoltani, Arghavan ; Manhanzva, Monalisa T ; Potgieter, Matthys ; Balle, Christina ; Bell, Liam ; Ross, Elizabeth ; Iranzadeh, Arash ; du Plessis, Michelle ; Radzey, Nina ; McDonald, Zac ; Calder, Bridget ; Allali, Imane ; Mulder, Nicola ; Dabee, Smritee ; Barnabas, Shaun ; Gamieldien, Hoyam ; Godzik, Adam ; Blackburn, Jonathan M ; Tabb, David L ; Bekker, Linda-Gail ; Jaspan, Heather B ; Passmore, Jo-Ann S ; Masson, Lindi Date: 21 Nov 2020 Abstract Background Female genital tract (FGT) inflammation is an important risk factor for HIV acquisition. The FGT microbiome is closely associated with inflammatory profile; however, the relative importance of microbial activities has ... Read more
Probiotics for vaginal health in South Africa: what is on retailers’ shelves?

Author: Happel, Anna-Ursula ; Jaumdally, Shameem Z ; Pidwell, Tanya ; Cornelius, Tracy ; Jaspan, Heather B ; Froissart, Remy ; Barnabas, Shaun L ; Passmore, Jo-Ann S Date: 19 Jan 2017 Background: Probiotics are widely used to improve gastrointestinal (GI) health, but they may also be useful to prevent or treat gynaecological disorders, including bacterial vaginosis (BV) and candidiasis. BV prevalence is high in South Africa ... Read more
The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: A retrospective cohort study

Author: Huang, Lyen C ; Myer, Landon ; Jaspan, Heather B Date: 2008 BACKGROUND:Mortality among HIV-infected children in developing countries remains high after serious bacterial infections despite the use of antibiotics. Intravenous immunoglobulin (IVIG) has been used as an adjuvant therapy to treat these ... Read more c b
Testing the regulatory framework in South Africa – a single-blind randomized pilot trial of commercial probiotic supplementation to standard therapy in women with bacterial vaginosis

Author: Happel, Anna-Ursula ; Singh, Ravesh ; Mitchev, Nireshni ; Mlisana, Koleka ; Jaspan, Heather B ; Barnabas, Shaun L ; Passmore, Jo-Ann S Date: 10 Jul 2020 Abstract Background Bacterial vaginosis (BV) increases HIV risk and adverse reproductive outcomes. Standard-of-care (SOC) for BV are antibiotics; however, cure rates are low. Probiotics for vaginal health may be useful in improving cure and ... Read more
Vaginal microbial diversity of the genital tract of South African adolescent females

Author: Breetzke, Aerin Olivia Date: 2017 Young, reproductive-aged women are at highest risk of acquiring human-immunodeficiency virus (HIV). The Women's Initiative in Sexual Health (WISH) study was designed to investigate potential biological reasons for this high risk in HIV negative, ... Read more

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