Browsing by Author "Greenberg, L Jacquie"

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Clinical and genetic analysis of spinocerebellar ataxia type 7 (SCA7) in Zambian families

Author: Atadzhanov, Masharip ; Smith, Danielle C ; Mwaba, Mwila H ; Siddiqi, Omar K ; Bryer, Alan ; Greenberg, L Jacquie Date: 29 Nov 2017 Background: To date, 43 types of Spinocerebellar Ataxias (SCAs) have been identified. A subset of the SCAs are caused by the pathogenic expansion of a CAG repeat tract within the corresponding gene. Ethnic and geographic differences are evident ... Read more
Design of RNAi hairpins for mutation-specific silencing of ataxin-7 and correction of a SCA7 phenotype

Author: Scholefield, Janine ; Greenberg, L Jacquie ; Weinberg, Marc S ; Arbuthnot, Patrick B ; Abdelgany, Amr ; Wood, Matthew J A Date: 2009 Spinocerebellar ataxia type 7 is a polyglutamine disorder caused by an expanded CAG repeat mutation that results in neurodegeneration. Since no treatment exists for this chronic disease, novel therapies such post-transcriptional RNA ... Read more c b

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