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Browsing by Author "Goliath, Rene"

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Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis

Author: van der Plas, Helen ; Meintjes, Graeme ; Schutz, Charlotte ; Goliath, Rene ; Myer, Landon ; Baatjie, Dorothea ; Wilkinson, Robert J ; Maartens, Gary ; Mendelson, Marc Date: 2013 BACKGROUND: HIV-associated tuberculosis is a common coinfection in Sub-Saharan Africa, which causes high morbidity and mortality. A sub-set of HIV-associated tuberculosis patients require prolonged hospital admission, during which antiretroviral ... Read more c b
Detailed investigation of the unstable (CAG) repeat and the immediate surrounding region of the IT15 gene in some South African families with Huntington disease

Author: Scholefield, Janine Date: 2005 The primary aim of this study was to investigate the origins of the HD mutation in South Africa (SA) by constructing a single nucleotide polymorphism (SNP) haplotype around the IT15 gene and to determine how many haplotypes there are in SA. ... Read more
Duchenne muscular dystrophy : mutation profiling in view of the emerging gene-based therapies

Author: Esterhuizen, Alina Date: 2010 Duchenne Muscular Dystrophy (DMD) is a lethal, X-linked, recessive muscle-wasting disorder affecting 1 in 3 500 live male births worldwide, for which only palliative care is available to date. Large exonic deletions or duplications are found ... Read more
Exploration of the impact of genetic counselling and patient support group involvement on retinal degenerative disorders (RDD) patients: a qualitative study

Author: Goliath, Rene Date: 2018 This study explored the experiences of individuals within the clinical genetic service in South Africa, with inherited retinal disease. Methods: This qualitative research was based on a grounded theory approach. Semi-structured interviews ... Read more
Prolonged tuberculosis-associated immune reconstitution inflammatory syndrome: characteristics and risk factors

Author: Bana, Tasnim M ; Lesosky, Maia ; Pepper, Dominique J ; van der Plas, Helen ; Schutz, Charlotte ; Goliath, Rene ; Morroni, Chelsea ; Mendelson, Marc ; Maartens, Gary ; Wilkinson, Robert J ; Meintjes, Graeme Date: 27 Sep 2016 Background: In a proportion of patients with HIV-associated tuberculosis who develop paradoxical immune reconstitution inflammatory syndrome (IRIS), the clinical course of IRIS is prolonged necessitating substantial health care utilization ... Read more c b
QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response

Author: Esmail, Hanif ; Thienemann, Friedrich ; Oni, Tolu ; Goliath, Rene ; Wilkinson, Katalin A ; Wilkinson, Robert J Date: 07 Oct 2016 Background: HIV-1 infection impairs tuberculosis (TB) specific immune responses affecting the diagnosis of latent TB. We aimed to (1) determine the proportion of HIV-1-infected adults with a negative QuantiFERON®-TB Gold in-tube (QFT-GIT) and ... Read more c b

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Browsing by Author "Goliath, Rene"

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