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Browsing by Author "Dorfman, Jeffrey Robert"

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Chinks in the armor of the HIV-1 Envelope glycan shield: implications for immune escape from anti-glycan broadly neutralizing antibodies

Author: Moyo, Thandeka ; Ferreira, Roux-cil ; Davids, Reyaaz ; Sonday, Zarinah ; Moore, Penny L ; Travers, Simon A ; Wood, Natasha T ; Dorfman, Jeffrey Robert Date: 15 Jan 2017 Glycans on HIV-1 Envelope serve multiple functions including blocking epitopes from antibodies. We show that removal of glycan 301, a major target of anti-V3/glycan antibodies, has substantially different effects in two viruses. While glycan ... Read more
High Degree of HIV-1 group M Genetic Diversity within Circulating Recombinant Forms: Insight into the Early Events of HIV-1M Evolution

Author: Tongo, Marcel ; Dorfman, Jeffrey Robert ; Martin, Darren Patrick Date: 15 Mar 2016 The existence of various highly divergent HIV-1 lineages and of recombination-derived sequence tracts of indeterminate origin within established circulating recombinant forms (CRFs) strongly suggests that HIV-1 group M (HIV-1M) diversity is ... Read more
The HIV‑1 transmission bottleneck

Author: Kariuki, Samuel Mundia ; Selhorst, Philippe ; Ariën, Kevin K ; Dorfman, Jeffrey Robert Date: 25 Mar 2017 It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations in the blood of the presumed donor ... Read more c b
Male genital tract versus blood HIV-1 compartmentalization and selection: the first step of the transmission bottleneck?

Author: Kariuki, Samuel Mundia Date: 2019 Introduction Sexual transmission of HIV-1 accounts for more than 80% of all the transmissions globally. After transmission, approximately 80% of the newly disseminated infections can be traced to a single variant, which comes from the minor ... Read more

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Browsing by Author "Dorfman, Jeffrey Robert"

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