Browsing by Author "Dorfman, Jeffrey R"

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Detectable HIV-1 in semen in individuals with very low blood viral loads

Author: Kariuki, Samuel M ; Selhorst, Philippe ; Norman, Jennifer ; Cohen, Karen ; Rebe, Kevin ; Williamson, Carolyn ; Dorfman, Jeffrey R Date: 05 Mar 2020 Abstract Background Several reports indicate that a portion (5–10%) of men living with HIV-1 intermittently shed HIV-1 RNA into seminal plasma while on long term effective antiretroviral therapy (ART). This is highly suggestive of an HIV-1 ... Read more
Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses

Author: Moyo, Thandeka Date: 2017 Understanding the mechanisms used by HIV-1 to evade antibody neutralisation may contribute to the design of a high-coverage vaccine. This thesis explores the mechanism used by a Tier 3 virus leading to its high antibody neutralisation resistance ... Read more
The HIV-1 transmission bottleneck

Author: Kariuki, Samuel M ; Selhorst, Philippe ; Ariën, Kevin K ; Dorfman, Jeffrey R Date: 23 Mar 2017 It is well established that most new systemic infections of HIV-1 can be traced back to one or a limited number of founder viruses. Usually, these founders are more closely related to minor HIV-1 populations in the blood of the presumed donor ... Read more

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