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Browsing by Author "Dawson, Rodney"

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Adenosine Deaminase Acting on RNA-1 (ADAR1) Inhibits HIV-1 Replication in Human Alveolar Macrophages

Author: Weiden, Michael D ; Hoshino, Satomi ; Levy, David N ; Li, Yonghua ; Kumar, Rajnish ; Burke, Sean A ; Dawson, Rodney ; Hioe, Catarina E ; Borkowsky, William ; Rom, William N ; Hoshino, Yoshihiko Date: 2014 While exploring the effects of aerosol IFN-γ treatment in HIV-1/tuberculosis co-infected patients, we observed A to G mutations in HIV-1 envelope sequences derived from bronchoalveolar lavage (BAL) of aerosol IFN-γ-treated patients and induction ... Read more c b
Brief psychotherapy administered by non-specialised health workers to address risky substance use in patients with multidrug-resistant tuberculosis: a feasibility and acceptability study

Author: Calligaro, Gregory L ; de Wit, Zani ; Cirota, Jacqui ; Orrell, Catherine ; Myers, Bronwyn ; Decker, Sebastian ; Stein, Dan J ; Sorsdahl, Katherine ; Dawson, Rodney Date: 19 Jan 2021 Background Only 55% of multidrug-resistant tuberculosis (MDR-TB) cases worldwide complete treatment, with problem substance use a risk for default and treatment failure. Nevertheless, there is little research on psychotherapeutic ... Read more c b
Clinical diagnostic utility of IP-10 and LAM antigen levels for the diagnosis of tuberculous pleural effusions in a high burden setting

Author: Dheda, Keertan ; Van-Zyl Smit, Richard N ; Sechi, Leonardo A ; Badri, Motasim ; Meldau, Richard ; Symons, Gregory ; Khalfey, Hoosein ; Carr, Igshaan ; Maredza, Alice ; Dawson, Rodney Date: 2009 BACKGROUND: Current tools for the diagnosis of tuberculosis pleural effusions are sub-optimal. Data about the value of new diagnostic technologies are limited, particularly, in high burden settings. Preliminary case control studies have ... Read more c b
Clinical utility of a commercial LAM-ELISA assay for TB diagnosis in HIV-infected patients using urine and sputum samples

Author: Dheda, Keertan ; Davids, Virginia ; Lenders, Laura ; Roberts, Teri ; Meldau, Richard ; Ling, Daphne ; Brunet, Laurence ; Smit, Richard van Zyl ; Peter, Jonathan ; Green, Clare ; Badri, Motasim ; Sechi, Leonardo ; Sharma, Surendra ; Hoelscher, Michael ; Dawson, Rodney Date: 2010 BACKGROUND: The accurate diagnosis of TB in HIV-infected patients, particularly with advanced immunosuppression, is difficult. Recent studies indicate that a lipoarabinomannan (LAM) assay (Clearview-TB®-ELISA) may have some utility for the ... Read more c b
Development of a simple reliable radiographic scoring system to aid the diagnosis of pulmonary tuberculosis

Author: Pinto, Lancelot M ; Dheda, Keertan ; Theron, Grant ; Allwood, Brian ; Calligaro, Gregory ; van Zyl-Smit, Richard ; Peter, Jonathan ; Schwartzman, Kevin ; Menzies, Dick ; Bateman, Eric ; Pai, Madhukar ; Dawson, Rodney Date: 2013 Rationale: Chest radiography is sometimes the only method available for investigating patients with possible pulmonary tuberculosis (PTB) with negative sputum smears. However, interpretation of chest radiographs in this context lacks specificity ... Read more c b
Increased production of IL-4 and IL-12p40 from bronchoalveolar lavage cells are biomarkers of Mycobacterium tuberculosis in the sputum

Author: Nolan, Anna ; Fajardo, Elaine ; Huie, Maryann L ; Condos, Rany ; Pooran, Anil ; Dawson, Rodney ; Dheda, Keertan ; Bateman, Eric ; Rom, William N ; Weiden, Michael D Date: 2013 BACKGROUND: Tuberculosis (TB) causes 1.45 million deaths annually world wide, the majority of which occur in the developing world. Active TB disease represents immune failure to control latent infection from airborne spread. Acid-fast bacillus ... Read more c b
Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

Author: Tweed, Conor D ; Wills, Genevieve H ; Crook, Angela M ; Dawson, Rodney ; Diacon, Andreas H ; Louw, Cheryl E ; McHugh, Timothy D ; Mendel, Carl ; Meredith, Sarah ; Mohapi, Lerato ; Murphy, Michael E ; Murray, Stephen ; Murthy, Sara ; Nunn, Andrew J ; Phillips, Patrick P J ; Singh, Kasha ; Spigelman, M ; Gillespie, S H Date: 28 Mar 2018 Background Drug-induced liver injury (DILI) is a common complication of tuberculosis treatment. We utilised data from the REMoxTB clinical trial to describe the incidence of predisposing factors and the natural history in ... Read more
Mycobactericidal activity of sutezolid (PNU-100480) in sputum (EBA) and blood (WBA) of patients with pulmonary tuberculosis

Author: Wallis, Robert S ; Dawson, Rodney ; Friedrich, Sven O ; Venter, Amour ; Paige, Darcy ; Zhu, Tong ; Silvia, Annette ; Gobey, Jason ; Ellery, Craig ; Zhang, Yao Date: 2014 Rationale: Sutezolid (PNU-100480) is a linezolid analog with superior bactericidal activity against Mycobacterium tuberculosis in the hollow fiber, whole blood and mouse models. Like linezolid, it is unaffected by mutations conferring resistance ... Read more c b
Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status

Author: Tweed, Conor D ; Crook, Angela M ; Dawson, Rodney ; Diacon, Andreas H ; McHugh, Timothy D ; Mendel, Carl M ; Meredith, Sarah K ; Mohapi, Lerato ; Murphy, Michael E ; Nunn, Andrew J ; Phillips, Patrick P J ; Singh, Kasha P ; Spigelman, Melvin ; Gillespie, Stephen H Date: 14 Aug 2019 Abstract Background The phase III REMoxTB study prospectively enrolled HIV-positive (with CD4+ count > 250 cells, not on anti-retroviral therapy) and HIV-negative patients. We investigated the ... Read more

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Browsing by Author "Dawson, Rodney"

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