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Browsing by Author "Chimusa, Emile R"

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A post-gene silencing bioinformatics protocol for plant-defence gene validation and underlying process identification: case study of the Arabidopsis thaliana NPR1

Author: Yocgo, Rosita E ; Geza, Ephifania ; Chimusa, Emile R ; Mazandu, Gaston K Date: 23 Nov 2017 Background: Advances in forward and reverse genetic techniques have enabled the discovery and identification of several plant defence genes based on quantifiable disease phenotypes in mutant populations. Existing models for testing the effect ... Read more
A post-gene silencing bioinformatics protocol for plant-defence gene validation and underlying process identification: case study of the Arabidopsis thaliana NPR1

Author: Yocgo, Rosita E ; Geza, Ephifania ; Chimusa, Emile R ; Mazandu, Gaston K Date: 2017 Advances in forward and reverse genetic techniques have enabled the discovery and identification of several plant defence genes based on quantifiable disease phenotypes in mutant populations. Existing models for testing the effect of gene ... Read more
ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations

Author: Chimusa, Emile R ; Mbiyavanga, Mamana ; Mazandu, Gaston K ; Mulder, Nicola J Date: 27 Despite numerous successful Genome-wide Association Studies (GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may miss disease genes with weak genetic effects or strong epistatic effects due to the single-marker ... Read more
Association of variants in APOL1, MYH9 and HMOX1 WITH micro-Albuminuria among Sickle Cell disease patients from Cameroon

Author: Geard, Amy Date: 2016 Introduction: Sickle Cell Disease (SCD) is a monogenic, multi-organ hemoglobinopathy disorder that is highly prevalent in Africa, with nearly 300 000 newborn cases per year. The underlying pathophysiological mechanism of the disease involves ... Read more
"Broadband" bioinformatics skills transfer with the Knowledge Transfer Programme (KTP): educational model for upliftment and sustainable development

Author: Chimusa, Emile R ; Mbiyavanga, Mamana ; Masilela, Velaphi ; Kumuthini, Judit Date: 2015 A shortage of practical skills and relevant expertise is possibly the primary obstacle to social upliftment and sustainable development in Africa. The "omics" fields, especially genomics, are increasingly dependent on the effective interpretation ... Read more c b
Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method

Author: Chimusa, Emile R ; Daya, Michelle ; Möller, Marlo ; Ramesar, Raj ; Henn, Brenna M ; van Helden, Paul D ; Mulder, Nicola J ; Hoal, Eileen G Date: 2013 Admixed populations can make an important contribution to the discovery of disease susceptibility genes if the parental populations exhibit substantial variation in susceptibility. Admixture mapping has been used successfully, but is not ... Read more c b
Dissecting the genetic bases of severe malaria resistance using genome-wide and post genomewide study approaches

Author: Mulisa, Delesa Damena Date: 2021 P. falciparum malaria remains one of the leading public health problems worldwide. The global tally of malaria in 2018 was estimated at 228 million cases and 405, 000 deaths worldwide. African countries disproportionately carry the global ... Read more
Functional Genome Wide Association Study in Susceptibility and Resistance of Malaria

Author: Kabongo, Etienne Ntumba Date: 2021 Background: More than century, malaria is qualified as a mortal infectious disease, worldwide causing high morbidity and mortality. The World Health Organization (WHO) has shown that, Distribution of Malaria in Africa takes a major part, it's ... Read more
Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects

Author: Damena, Delesa ; Denis, Awany ; Golassa, Lemu ; Chimusa, Emile R Date: 14 Aug 2019 Abstract Background P. falciparum malaria has been recognized as one of the prominent evolutionary selective forces of human genome that led to the emergence of multiple host protective alleles. ... Read more
A Genomic Portrait of Haplotype Diversity and Signatures of Selection in Indigenous Southern African Populations

Author: Chimusa, Emile R ; Meintjies, Ayton ; Tchanga, Milaine ; Mulder, Nicola ; Seoighe, Cathal ; Soodyall, Himla ; Ramesar, Rajkumar Date: 2015 We report a study of genome-wide, dense SNP (∼900K) and copy number polymorphism data of indigenous southern Africans. We demonstrate the genetic contribution to southern and eastern African populations, which involved admixture between ... Read more c b
Identifying Genes and Novel Variants Involved in Nonsyndromic Hearing Impairment, and Assessment of the Psychosocial Burden of Hearing Impairment in Cameroon

Author: Wonkam, Tingang Edmond Date: 2021 Background Hearing impairment (HI) is the most common sensory disability and occurs in about 1 per 1000 live births in high-income countries, with a much higher incidence of up to 6 per 1000 live births in sub-Saharan Africa (SSA). HI can be ... Read more
Integration of multi-omic data and neuroimaging characteristics in studying brain related diseases

Author: Elsheikh, Samar Salah Mohamedahmed Date: 2020 Approaches to the identification of genetic variants associated with complex brain diseases have evolved in recent decades. This evolution was supported by advancements in medical imaging and genotyping technologies that result in rich data ... Read more
Large–scale data–driven network analysis of human–plasmodium falciparum interactome: extracting essential targets and processes for malaria drug discovery

Author: Agamah, Francis Edem Date: 2020 Background: Plasmodium falciparum malaria is an infectious disease considered to have great impact on public health due to its associated high mortality rates especially in sub Saharan Africa. Falciparum drugresistant strains, notably, to ... Read more
Leveraging genotypes imputation and polygenic risk scores in malaria susceptibility

Author: Kimathi, Peter Opiyo Date: 2020 Background Over the past few years, Genome Wide Association Studies (GWAS) have identified thousands of genetic variants that are associated with a wide range of complex traits, and have provided valuable insights as far as their genetic ... Read more
Leveraging the microbiome in host genome wide association studies

Author: Awany, Denis Date: 2021 Genome-wide association study (GWAS) has emerged as an effective method for detecting genetic polymorphisms associated with expressed phenotypes. Over the past decade, GWAS of human traits and diseases has revolutionized the field of complex ... Read more
Leveraging Whole Genome Sequences to Compare Mutational Mechanism and Identify Medically Relevant Variation in African versus Non-African Descend Populations

Author: Alosaimi, Shatha Mobarak Date: 2020 Whole-Genome Sequencing (WGS) is ushering a new era in healthcare and research in identifying genetic variation in all populations. However, the African populations are still under-represented. Since African populations are being the most ... Read more
A panel of ancestry informative markers for the complex five-way admixed South African Coloured population

Author: Daya, Michelle ; Merwe, Lize van der ; Galal, Ushma ; Möller, Marlo ; Salie, Muneeb ; Chimusa, Emile R ; Galanter, Joshua M ; Helden, Paul D van ; Henn, Brenna M ; Gignoux, Chris R Date: 2013 Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust for admixture. The ... Read more c b

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Browsing by Author "Chimusa, Emile R"

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