Author:Yocgo, Rosita E; Geza, Ephifania; Chimusa, Emile R; Mazandu, Gaston KDate:23 Nov 2017Background: Advances in forward and reverse genetic techniques have enabled the discovery and identification of several plant defence genes based on quantifiable disease phenotypes in mutant populations. Existing models for testing the effect ...Read more
Author:Yocgo, Rosita E; Geza, Ephifania; Chimusa, Emile R; Mazandu, Gaston KDate:2017Advances in forward and reverse genetic techniques have enabled the discovery and identification of several plant defence genes based on quantifiable disease phenotypes in mutant populations. Existing models for testing the effect of gene ...Read more
Author:Chimusa, Emile R; Mbiyavanga, Mamana; Mazandu, Gaston K; Mulder, Nicola JDate:27Despite numerous successful Genome-wide Association Studies (GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may miss disease genes with weak genetic effects or strong epistatic effects due to the single-marker ...Read more
Author:Geard, AmyDate:2016Introduction: Sickle Cell Disease (SCD) is a monogenic, multi-organ hemoglobinopathy disorder that is highly prevalent in Africa, with nearly 300 000 newborn cases per year. The underlying pathophysiological mechanism of the disease involves ...Read more
Author:Chimusa, Emile R; Mbiyavanga, Mamana; Masilela, Velaphi; Kumuthini, JuditDate:2015A shortage of practical skills and relevant expertise is possibly the primary obstacle to social upliftment and sustainable development in Africa. The "omics" fields, especially genomics, are increasingly dependent on the effective interpretation ...Read morecb
Author:Mulisa, Delesa DamenaDate: 2021P. falciparum malaria remains one of the leading public health problems worldwide. The global tally of malaria in 2018 was estimated at 228 million cases and 405, 000 deaths worldwide. African countries disproportionately carry the global ...Read more
Author:Kabongo, Etienne NtumbaDate: 2021Background: More than century, malaria is qualified as a mortal infectious disease, worldwide causing high morbidity and mortality. The World Health Organization (WHO) has shown that, Distribution of Malaria in Africa takes a major part, it's ...Read more
Author:Damena, Delesa; Denis, Awany; Golassa, Lemu; Chimusa, Emile RDate:14 Aug 2019Abstract
Background
P. falciparum malaria has been recognized as one of the prominent evolutionary selective forces of human genome that led to the emergence of multiple host protective alleles. ...Read more
Author:Wonkam, Tingang EdmondDate: 2021Background Hearing impairment (HI) is the most common sensory disability and occurs in about 1 per 1000 live births in high-income countries, with a much higher incidence of up to 6 per 1000 live births in sub-Saharan Africa (SSA). HI can be ...Read more
Author:Elsheikh, Samar Salah MohamedahmedDate:2020Approaches to the identification of genetic variants associated with complex brain diseases have evolved in recent decades. This evolution was supported by advancements in medical imaging and genotyping technologies that result in rich data ...Read more
Author:Agamah, Francis EdemDate: 2020Background: Plasmodium falciparum malaria is an infectious disease considered to have great impact on public health due to its associated high mortality rates especially in sub Saharan Africa. Falciparum drugresistant strains, notably, to ...Read more
Author:Kimathi, Peter OpiyoDate: 2020Background Over the past few years, Genome Wide Association Studies (GWAS) have identified thousands of genetic variants that are associated with a wide range of complex traits, and have provided valuable insights as far as their genetic ...Read more
Author:Awany, DenisDate: 2021Genome-wide association study (GWAS) has emerged as an effective method for detecting genetic polymorphisms associated with expressed phenotypes. Over the past decade, GWAS of human traits and diseases has revolutionized the field of complex ...Read more
Author:Alosaimi, Shatha MobarakDate:2020Whole-Genome Sequencing (WGS) is ushering a new era in healthcare and research in identifying genetic variation in all populations. However, the African populations are still under-represented. Since African populations are being the most ...Read more