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Browsing by Author "Chimusa, Emile R"

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A post-gene silencing bioinformatics protocol for plant-defence gene validation and underlying process identification: case study of the Arabidopsis thaliana NPR1

Author: Yocgo, Rosita E ; Geza, Ephifania ; Chimusa, Emile R ; Mazandu, Gaston K Date: 23 Nov 2017 Background: Advances in forward and reverse genetic techniques have enabled the discovery and identification of several plant defence genes based on quantifiable disease phenotypes in mutant populations. Existing models for testing the effect ... Read more
ancGWAS: a post genome-wide association study method for interaction, pathway and ancestry analysis in homogeneous and admixed populations

Author: Chimusa, Emile R ; Mbiyavanga, Mamana ; Mazandu, Gaston K ; Mulder, Nicola J Date: 27 Despite numerous successful Genome-wide Association Studies (GWAS), detecting variants that have low disease risk still poses a challenge. GWAS may miss disease genes with weak genetic effects or strong epistatic effects due to the single-marker ... Read more
Association of variants in APOL1, MYH9 and HMOX1 WITH micro-Albuminuria among Sickle Cell disease patients from Cameroon

Author: Geard, Amy Date: 2016 Introduction: Sickle Cell Disease (SCD) is a monogenic, multi-organ hemoglobinopathy disorder that is highly prevalent in Africa, with nearly 300 000 newborn cases per year. The underlying pathophysiological mechanism of the disease involves ... Read more
"Broadband" bioinformatics skills transfer with the Knowledge Transfer Programme (KTP): educational model for upliftment and sustainable development

Author: Chimusa, Emile R ; Mbiyavanga, Mamana ; Masilela, Velaphi ; Kumuthini, Judit Date: 2015 A shortage of practical skills and relevant expertise is possibly the primary obstacle to social upliftment and sustainable development in Africa. The "omics" fields, especially genomics, are increasingly dependent on the effective interpretation ... Read more c b
Determining ancestry proportions in complex admixture scenarios in South Africa using a novel proxy ancestry selection method

Author: Chimusa, Emile R ; Daya, Michelle ; Möller, Marlo ; Ramesar, Raj ; Henn, Brenna M ; van Helden, Paul D ; Mulder, Nicola J ; Hoal, Eileen G Date: 2013 Admixed populations can make an important contribution to the discovery of disease susceptibility genes if the parental populations exhibit substantial variation in susceptibility. Admixture mapping has been used successfully, but is not ... Read more c b
A Genomic Portrait of Haplotype Diversity and Signatures of Selection in Indigenous Southern African Populations

Author: Chimusa, Emile R ; Meintjies, Ayton ; Tchanga, Milaine ; Mulder, Nicola ; Seoighe, Cathal ; Soodyall, Himla ; Ramesar, Rajkumar Date: 2015 We report a study of genome-wide, dense SNP (∼900K) and copy number polymorphism data of indigenous southern Africans. We demonstrate the genetic contribution to southern and eastern African populations, which involved admixture between ... Read more c b
A panel of ancestry informative markers for the complex five-way admixed South African Coloured population

Author: Daya, Michelle ; Merwe, Lize van der ; Galal, Ushma ; Möller, Marlo ; Salie, Muneeb ; Chimusa, Emile R ; Galanter, Joshua M ; Helden, Paul D van ; Henn, Brenna M ; Gignoux, Chris R Date: 2013 Admixture is a well known confounder in genetic association studies. If genome-wide data is not available, as would be the case for candidate gene studies, ancestry informative markers (AIMs) are required in order to adjust for admixture. The ... Read more c b

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Browsing by Author "Chimusa, Emile R"

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