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Browsing by Author "Chapman, Rosamund"

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Advancements in the Growth and Construction of Recombinant Lumpy Skin Disease Virus (LSDV) for Use as a Vaccine Vector

Author: van Diepen, Michiel ; Chapman, Rosamund ; Douglass, Nicola ; Whittle, Leah ; Chineka, Nicole ; Galant, Shireen ; Cotchobos, Christian ; Suzuki, Akiko ; Williamson, Anna-Lise Date: 04 Oct 2021 Attenuated vaccine strains of lumpy skin disease virus (LSDV) have become increasingly popular as recombinant vaccine vectors, to target both LSDV, as well as other pathogens, including human infectious agents. Historically, these vaccine ... Read more c b
Development and characterisation of recombinant LSDV-vectored dual vaccines against bovine leukaemia virus and lumpy skin disease virus

Author: Suzuki, Akiko Date: 2019 Bovine leukaemia virus (BLV) and lumpy skin disease virus (LSDV) are endemic to Africa and cause significant economic losses to the beef and dairy industries. Vaccines are the most cost-effective and efficient way to prevent infection and ... Read more
The development of novel HIV-1 vaccines using modified recombinant BCG

Author: Chetty, Shivan Date: 2016 Vaccination continues to represent the most effective means of providing immunological protection against infectious disease in human populations. With the World Health Organisation (WHO) reporting over 1.2 million AIDS related deaths in 2014, ... Read more
Optimisation of the mycobacterial replicon of an E. coli-mycobacterial shuttle vector

Author: Griffin, Sarah Date: 2007 This study aimed to investigate whether the mycobacterial replicon may also play a role. The common mycobacterial replicon in episomal E. coli-mycobacterial shuttle vectors contains the truncated rap gene, encoding an auxiliary replication ... Read more
Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells

Author: Chapman, Rosamund ; Shephard, Enid ; Stutz, Helen ; Douglass, Nicola ; Sambandamurthy, Vasan ; Garcia, Irene ; Ryffel, Bernhard ; Jacobs, William ; Williamson, Anna-Lise Date: 2012 A safe and effective HIV vaccine is required to significantly reduce the number of people becoming infected with HIV each year. In this study wild type Mycobacterium bovis BCG Pasteur and an attenuated pantothenate auxotroph strain (BCGΔ panCD ... Read more c b
Priming with recombinant auxotrophic BCG expressing HIV-1 Gag, RT and Gp120 and boosting with recombinant MVA induces a robust T cell response in mice

Author: Chapman, Rosamund ; Stutz, Helen ; Jr, William Jacobs ; Shephard, Enid ; Williamson, Anna-Lise Date: 2013 In previous studies we have shown that a pantothenate auxotroph of Myocbacterium bovis BCG (BCGΔ panCD ) expressing HIV-1 subtype C Gag induced Gag-specific immune responses in mice and Chacma baboons after prime-boost immunization in combination ... Read more c b
The use of directed evolution to create a stable and immunogenic recombinant BCG expressing a modified HIV-1 Gag antigen

Author: Chapman, Rosamund ; Bourn, William R ; Shephard, Enid ; Stutz, Helen ; Douglass, Nicola ; Mgwebi, Thandi ; Meyers, Ann ; Chin'ombe, Nyasha ; Williamson, Anna-Lise Date: 2014 Numerous features make Mycobacterium bovis BCG an attractive vaccine vector for HIV. It has a good safety profile, it elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable. Despite these advantages ... Read more c b

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Browsing by Author "Chapman, Rosamund"

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