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Browsing by Author "Bateman, Eric D"

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A blinded evaluation of the efficacy and safety of glycopyrronium, a once-daily long-acting muscarinic antagonist, versus tiotropium, in patients with COPD: the GLOW5 study

Author: Chapman, Kenneth R ; Beeh, Kai-Michael ; Beier, Jutta ; Bateman, Eric D ; D’Urzo, Anthony ; Nutbrown, Robert ; Henley, Michelle ; Chen, Hungta ; Overend, Tim ; D’Andrea, Peter Date: 17 Jan 2014 Abstract Background Two once-daily long-acting muscarinic antagonists (LAMAs) are currently available for the treatment of chronic obstructive pulmonary disease (COPD) – tiotropium and ... Read more c b
Cigarette smoke and human pulmonary immune responses to mycobacteria

Author: Van Zyl-Smit, Richard Nellis Date: 2011 Recent epidemiological evidence suggests that up to 15% of worldwide tuberculosis (TB) cases may be attributable to tobacco smoking. The aim of the studies reported here was to gain insights into the effects of exposure to cigarette smoke on ... Read more
Comparison of quantitative techniques including Xpert MTB/RIF to evaluate mycobacterial burden

Author: van Zyl-Smit, Richard N ; Binder, Anke ; Meldau, Richard ; Mishra, Hridesh ; Semple, Patricia L ; Theron, Grant ; Peter, Jonathan ; Whitelaw, Andrew ; Sharma, Suren K ; Warren, Robin ; Bateman, Eric D ; Dheda, Keertan Date: 2011 Introduction: Accurate quantification of mycobacterial load is important for the evaluation of patient infectiousness, disease severity and monitoring treatment response in human and in-vitro laboratory models of disease. We hypothesized that ... Read more c b
Comparison of vilanterol, a novel long-acting beta2 agonist, with placebo and a salmeterol reference arm in asthma uncontrolled by inhaled corticosteroids

Author: Lötvall, Jan ; Bateman, Eric D ; Busse, William W ; O’Byrne, Paul M ; Woodcock, Ashley ; Toler, William T ; Jacques, Loretta ; Goldfrad, Caroline ; Bleecker, Eugene R Date: 13 Jun 2014 Background: Current maintenance therapies for asthma require twice-daily dosing. Vilanterol (VI) is a novel long-acting beta2 agonist, under development in combination with fluticasone furoate, a new inhaled corticosteroid (ICS). Findings ... Read more c b
The development and validation of a respiratory guideline for nurses in primary care in South Africa

Author: English, René Glynnis Date: 2006 The Practical Aproach to Lung Health in South Africa (P ALSA) initiative aims to improve the diagnosis and management of patients with respiratory diseases in primary care. An algorithm-based syndromic guideline integrating common respiratory ... Read more
Diagnostic, prognostic and therapeutic considerations in primary pulmonary hypertension

Author: Chapman, P J Date: 1987 The diagnosis of primary pulmonary hypertension (PPH) and prediction of its course, whether treated or untreated, presents several problems. These are of particular relevance when selection of patients for, and timing of heart-lung transplantation ... Read more
Efficacy and safety of fluticasone furoate 100 μg and 200 μg once daily in the treatment of moderate-severe asthma in adults and adolescents: a 24-week randomised study

Author: Woodcock, Ashley ; Lötvall, Jan ; Busse, William W ; Bateman, Eric D ; Stone, Sally ; Ellsworth, Anna ; Jacques, Loretta Date: 09 Jul 2014 Background: Inhaled corticosteroids are a mainstay of therapy for persistent asthma, but suboptimal adherence with twice-daily use is widespread. Fluticasone furoate (FF) is a new inhaled corticosteroid (ICS) suitable for once-daily dosing ... Read more c b
Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease

Author: Jones, Paul W ; Rennard, Stephen I ; Agusti, Alvar ; Chanez, Pascal ; Magnussen, Helgo ; Fabbri, Leonardo ; Donohue, James F ; Bateman, Eric D ; Gross, Nicholas J ; Lamarca, Rosa ; Caracta, Cynthia ; Gil, Esther G Date: 26 Apr 2011 Background: The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD). Methods: In two double-blind, ... Read more c b
Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial

Author: Woodcock, Ashley ; Bateman, Eric D ; Busse, William W ; Lötvall, Jan ; Snowise, Neil G ; Forth, Richard ; Jacques, Loretta ; Haumann, Brett ; Bleecker, Eugene R Date: 01 Dec 2011 Background: Fluticasone furoate (FF) is a novel long-acting inhaled corticosteroid (ICS). This double-blind, placebocontrolled randomized study evaluated the efficacy and safety of FF 200 mcg or 400 mcg once daily, either in the morning or ... Read more c b
Efficacy in asthma of once-daily treatment with fluticasone furoate: a randomized, placebo-controlled trial

Author: Woodcock, Ashley ; Bateman, Eric D ; Busse, William W ; Lotvall, Jan ; Snowise, Neil G ; Forth, Richard ; Jacques, Loretta ; Haumann, Brett ; Bleecker, Eugene R Date: 2011 BACKGROUND: Fluticasone furoate (FF) is a novel long-acting inhaled corticosteroid (ICS). This double-blind, placebo-controlled randomized study evaluated the efficacy and safety of FF 200 mcg or 400 mcg once daily, either in the morning or ... Read more c b
Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma

Author: Woodcock, Ashley ; Bleecker, Eugene R ; Busse, William W ; Lotvall, Jan ; Snowise, Neil G ; Frith, Lucy ; Jacques, Loretta ; Haumann, Brett ; Bateman, Eric D Date: 2011 BACKGROUND: Inhaled corticosteroids are the recommended first-line treatment for asthma but adherence to therapy is suboptimal. The objectives of this study were to compare the efficacy and safety of once-daily (OD) evening and twice-daily ... Read more c b
Hut lung : a study of domestically acquired pneumoconiosis in rural women

Author: Grobbelaar, Johannes P Date: 1987 Pneumoconiosis in rural Transkeian women termed "Transkei Silicosis" has been thought to be caused by silica inhaled while grinding maize by traditional methods (Palmer and Daynes, 1967). This study was undertaken to investigate the features ... Read more
Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps

Author: Bateman, Eric D ; Harrison, Tim W ; Quirce, Santiago ; Reddel, Helen K ; Buhl, Roland ; Humbert, Marc ; Jenkins, Christine R ; Peterson, Stefan ; Östlund, Ollie ; O'Byrne, Paul M ; Sears, Malcolm R ; Eriksson, Göran S Date: 01 Dec 2011 Background: Adjusting medication for uncontrolled asthma involves selecting one of several options from the same or a higher treatment step outlined in asthma guidelines. We examined the relative benefit of introducing budesonide/formoterol ... Read more
Pneumonia in HIV-infected children admitted to hospital in Cape Town, South Africa

Author: Zar, Heather Date: 2000 There is little information on the aetiology and outcome of HIV-associated pneumonia in African children and no comprehensive data from South Africa. Studies of HIV-infected adult in Africa reported that the spectrum of pulmonary disease ... Read more
Respiratory symptoms and chronic obstructive pulmonary disease : prevalence and risk factors in a predominantly low-income urban area of Cape Town, South Africa

Author: Jithoo, Anamika Date: 2006 The continuing worldwide increase in the incidence of chronic obstructive pulmonary disease (COPD) has led to international initiatives to improve surveillance and identify preventable risk factors for this and related chronic lung diseases. ... Read more
Risk factors for prolonged ventilation in patients with chronic obstructive pulmonary disease presenting with acute respiratory failure

Author: Van der Schyff, Nasief Date: 2009 Patients with COPD presenting to the Emergency Unit with acute hypercapnic respiratory failure often require invasive mechanical ventilation and subsequent admission to the intensive care unit (ICU). These patients are at an increased risk ... Read more
Risk factors for tuberculosis in a low-income urban area of Cape Town, South Africa, with particular reference to the role of cannabis smoking

Author: Jithoo, Anamika Date: 2007 Background: The association between Mycobacterium tuberculosis infection and tobacco smoking has recently been highlighted. The reason for this association remains unclear, but is postulated to result from the effects of smoking on pulmonary ... Read more
Silicosis among Cape gemstone workers : tigers' eye pneumoconiosis

Author: White, Neil W Date: 1991 Silicosis continues to be an important occupational disease in South Africa, particularly in small, poorly regulated industries. A case series is described of six workers who developed silicosis whilst involved in the processing of semi-precious ... Read more
A systematic review of the association between pulmonary tuberculosis and the development of chronic airflow obstruction in adults

Author: Allwood, Brian Date: 2012 Pulmonary tuberculosis (TB) as a cause of COPD is debated, with some, but not all evidence suggesting an association between the two conditions. Aim: To systematically review evidence for the association between pulmonary tuberculosis and the ... Read more
The burden of chronic respiratory disease in the Western Cape

Author: Carkeek, Emma Claire Date: 2018 Chronic respiratory disease (CRD), comprised mainly of asthma and chronic obstructive lung disease (COPD), is responsible for significant morbidity and mortality worldwide. Although asthma and COPD cannot be cured, they can be controlled using ... Read more

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