Browsing by Author "van Helden, Paul"

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High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South african patients with extensively drug-resistant tuberculosis

Author: Pietersen, Elize ; Peter, Jonny ; Streicher, Elizabeth ; Sirgel, Frik ; Rockwood, Neesha ; Mastrapa, Barbara ; Te Riele, Julian ; Davids, Malika ; van Helden, Paul ; Warren, Robin ; Dheda, Keertan Date: 2015 BACKGROUND: There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin achieves high serum concentrations relative to MIC but whether capreomycin ... Read more c b
High yield of culture-based diagnosis in a TB-endemic setting

Author: Demers, Anne-Marie ; Verver, Suzanne ; Boulle, Andrew ; Warren, Robin ; van Helden, Paul ; Behr, Marcel ; Coetzee, David Date: 2012 BACKGROUND: In most of the world, microbiologic diagnosis of tuberculosis (TB) is limited to microscopy. Recent guidelines recommend culture-based diagnosis where feasible. METHODS: In order to evaluate the relative and absolute incremental ... Read more c b

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