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Browsing by Author "Zerbini, Luiz Fernando"

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Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment

Author: Vava, Akhona Date: 2020 DCUN1D1 is an E3 ligase of the neddylation pathway. It mediates the posttranslational modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, ... Read more
Characterising the mechanism of DCUN1D1 activity in prostate cancer and identifying DCUN1D1 inhibitors for prostate cancer treatment

Author: Vava, Akhona Date: 2020 DCUN1D1 is an E3 ligase of the neddylation pathway. It mediates the posttranslational modification of majority of the cullin family of proteins with NEDD8. This activity is known to enhance ubiquitination of the cullin RING E3 ligases, however, ... Read more
SB225002 induces cell death and cell cycle arrest in acute lymphoblastic leukemia cells through the activation of GLIPR1

Author: De Vasconcellos, Jaíra Ferreira ; Laranjeira, Angelo Brunelli Albertoni ; Leal, Paulo C ; Bhasin, Manoj K ; Zenatti, Priscila Pini ; Nunes, Ricardo J ; Yunes, Rosendo A ; Nowill, Alexandre E ; Libermann, Towia A ; Zerbini, Luiz Fernando ; Yunes, José Andrés Date: 2015 Acute Lymphoblastic Leukemia (ALL) is the most frequent childhood malignancy. In the effort to find new anti-leukemic agents, we evaluated the small drug SB225002 (N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea). Although initially described ... Read more c b

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Browsing by Author "Zerbini, Luiz Fernando"

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