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Browsing by Author "Zembe, Lycias"

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Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic

Author: Tongo, Marcel ; Martin, Darren ; Zembe, Lycias ; Mpoudi-Ngole, Eitel ; Williamson, Carolyn ; Burgers, Wendy Date: 2013 BACKGROUND: Cameroon, in west central Africa, has an extraordinary degree of HIV diversity, presenting a major challenge for the development of an effective HIV vaccine. Given the continuing need to closely monitor the emergence of new HIV ... Read more c b
Intra-and inter-clade cross-reactivity by HIV-1 Gag specific T-cells reveals exclusive and commonly targeted regions: implications for current vaccine trials

Author: Zembe, Lycias ; Burgers, Wendy A ; Jaspan, Heather B ; Bekker, Linda-Gail ; Bredell, Helba ; Stevens, Gwynneth ; Gilmour, Jill ; Cox, Josephine H ; Fast, Patricia ; Hayes, Peter Date: 2011 The genetic diversity of HIV-1 across the globe is a major challenge for developing an HIV vaccine. To facilitate immunogen design, it is important to characterize clusters of commonly targeted T-cell epitopes across different HIV clades. To ... Read more c b
Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa

Author: Zembe, Lycias Date: 2007 The increasing diversity of HIV-1 in different geographic regions presents a challenge for the development of an HIV/AIDS vaccine. Even if proven effective, the ability of a vaccine to have cross-subtype and intra-subtype protection remains ... Read more
Investigating cross-clade immune responses in HIV-1 subtype C-infected individuals from South Africa: implications for HIV vaccine design

Author: Zembe, Lycias Date: 2012 Background An effective HIV vaccine remains the main hope for controlling the HIV epidemic and is a global health priority. The genetic diversity of the virus across the globe is a major impediment to developing an effective vaccine. Whether ... Read more

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