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Browsing by Author "Williamson, Anna-Lise"

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A deletion and point mutation study of the human papillomavirus type 16 major capsid gene

Author: Varsani, Arvind ; Williamson, Anna-Lise ; Jaffer, Mohamed A ; Rybicki, Edward P Date: 2006 Recombinant human papillomavirus (HPV) virus-like particles (VLPs) made from the major capsid protein L1 are promising vaccine candidates for use as vaccines against genital and other HPV infections, and particularly against HPV-16. However, ... Read more
A Study of Genital Human Papillomavirus (HPV) and Evaluation of HPV Testing for Cervical Cancer Screening in Women from the Eastern Cape Province, South Africa

Author: Taku, Ongeziwe Date: 2021 Introduction: Human papillomavirus (HPV) infection is an important public health problem facing black African women. Persistent infection with high-risk (HR) HPV types is the key factor for the development of cervical cancer. Coinfection of ... Read more
A study of the genital microbiotas of black South African women and men: associations with human papillomavirus and HIV infections

Author: Onywera, David Harris Date: 2018 Persistent genital infection with oncogenic or high-risk human papillomavirus (HPV) is causally associated with cervical cancer in women and some penile cancers in men. The role of the complex genital microbiota in HPV infection has not been ... Read more
Abrogation of contaminating RNA activity in HIV-1 Gag VLPs

Author: Valley-Omar, Ziyaad ; Meyers, Ann ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward Date: 2011 BACKGROUND: HIV-1 Gag virus like particles (VLPs) used as candidate vaccines are regarded as inert particles as they contain no replicative nucleic acid, although they do encapsidate cellular RNAs. During HIV-1 Gag VLP production in ... Read more c b
Advancements in the Growth and Construction of Recombinant Lumpy Skin Disease Virus (LSDV) for Use as a Vaccine Vector

Author: van Diepen, Michiel ; Chapman, Rosamund ; Douglass, Nicola ; Whittle, Leah ; Chineka, Nicole ; Galant, Shireen ; Cotchobos, Christian ; Suzuki, Akiko ; Williamson, Anna-Lise Date: 04 Oct 2021 Attenuated vaccine strains of lumpy skin disease virus (LSDV) have become increasingly popular as recombinant vaccine vectors, to target both LSDV, as well as other pathogens, including human infectious agents. Historically, these vaccine ... Read more c b
The allelic distribution of -308 Tumor Necrosis Factor-alpha gene polymorphism in South African women with cervical cancer and control women

Author: Govan, Vandana ; Constant, Debbie ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2006 BACKGROUND:Cervical cancer is due to infection with specific high-risk types of human papillomavirus (HPV). Although the incidence of genital HPV infection in various population groups is high, most of these regress without intervention. ... Read more c b
Assessment of an LSDV-Vectored Vaccine for Heterologous Prime-Boost Immunizations against HIV

Author: Chapman, Ros ; van Diepen, Michiel ; Douglass, Nicola ; Galant, Shireen ; Jaffer, Mohamed ; Margolin, Emmanuel ; Ximba, Phindile ; Hermanus, Tandile ; Moore, Penny L ; Williamson, Anna-Lise Date: 05 Nov 2021 The modest protective effects of the RV144 HIV-1 vaccine trial have prompted the further exploration of improved poxvirus vector systems that can yield better immune responses and protection. In this study, a recombinant lumpy skin disease ... Read more c b
CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

Author: Chatterjee, Koushik ; Dandara, Collet ; Hoffman, Margaret ; Williamson, Anna-Lise Date: 2010 BACKGROUND: Cervical cancer, caused by specific oncogenic types of human papillomavirus (HPV), is the second most common cancer in women worldwide. A large number of young sexually active women get infected by HPV but only a small fraction ... Read more c b
Cellular immune responses to human papillomavirus (HPV) type 16 at the cervix of women with HPV-associated squamous intraepithelial neoplasia

Author: Milner, Michelle Date: 2005 Cervical cancer is the most common cause of cancer-related death in black South African women. Human papillomavirus (HPV) has been found to be a necessary causative agent of cervical cancer and has been reported to be associated with 84% of ... Read more
Characterisation and evolutionary dynamics of ten novel Gammapapillomavirus types from South African penile swabs

Author: Murahwa, Alltalents Tutsirayi Date: 2019 Human papillomaviruses (HPVs) are genetically diverse, belonging to five distinct genera: Alpha, Beta, Gamma, Mu and Nu. We discovered ten novel Gammapapillomaviruses (Gamma-HPVs). Genomic characterisation and phylogenetic evaluation of the ... Read more
Characterization of a Novel Chimeric Theileria parva p67 Antigen Which Incorporates into Virus-like Particles and Is Highly Immunogenic in Mice

Author: Whittle, Leah ; Chapman, Ros ; van Diepen, Michiel ; Rybicki, Edward P ; Williamson, Anna-Lise Date: 28 Jan 2022 The current method to protect cattle against East Coast Fever (ECF) involves the use of live <i>Theileria parva</i> sporozoites. Although this provides immunity, using live parasites has many disadvantages, such as contributing to the spread ... Read more c b
Chimaeric HIV-1 subtype C Gag molecules with large in-frame C-terminal polypeptide fusions form virus-like particles.

Author: Halsey, Richard J ; Tanzer, Fiona L ; Meyers, Ann ; Pillay, Sirika ; Lynch, Alisson ; Shephard, Enid ; Williamson, Anna-Lise ; Rybicki, Edward P Date: 2008 HIV-1 Pr55 Gag virus-like particles (VLPs) are strong immunogens with potential as candidate HIV vaccines. VLP immunogenicity can be broadened by making chimaeric Gag molecules: however, VLPs incorporating polypeptides longer than 200 aa fused ... Read more
Clinical validation of the HPVIR high-risk HPV test on cervical samples according to the international guidelines for human papillomavirus DNA test requirements for cervical cancer screening

Author: Gustavsson, Inger ; Aarnio, Riina ; Myrnäs, Mattias ; Hedlund-Lindberg, Julia ; Taku, Ongeziwe ; Meiring, Tracy ; Wikström, Ingrid ; Enroth, Stefan ; Williamson, Anna-Lise ; Olovsson, Matts ; Gyllensten, Ulf Date: 22 Aug 2019 Abstract Background The indicating FTA card is a dry medium used for collection of cervical samples. HPVIR is a multiplex real-time PCR test that detects 12 high-risk human papillomavirus types ... Read more
Comparative analysis of avian poxvirus genomes, including a novel poxvirus from lesser flamingos (Phoenicopterus minor), highlights the lack of conservation of the central region

Author: Carulei, Olivia ; Douglass, Nicola ; Williamson, Anna-Lise Date: 06 Dec 2017 Background: Avian poxviruses are important pathogens of both wild and domestic birds. To date, seven isolates from subclades A and B and one from proposed subclade E, have had their genomes completely sequenced. The genomes of these isolates ... Read more
A comparative analysis of cowpox virus (CPV WT) and a deletion mutant lacking the gene encoding the inflammation modulatory protein (CPV IMP)

Author: Paulsen, Janis Date: 2007 Cowpox virus has been found to encode the inflammation modulatory protein (IMP) (Miller, C.G., 1997), a homologue vaccinia virus complement control protein (VCP). VCP belongs to regulation of complement activation (RCA) protein superfamily. ... Read more
Comparison of the two lumpy skin disease virus vaccines, Neethling and Herbivac, and construction of a recombinant Herbivac-Rift Valley fever virus vaccine

Author: Omar, Ruzaiq Date: 2015 There are two broad aims to this project. The first aim is to compare and characterise two lumpy skin disease virus (LSDV) vaccines namely the vaccine based on attenuated Neethling LSDV (nLSDV) and HerbivacÂ®LS (Herbivac). The second aim is ... Read more
Construction and evaluation of three candidate vaccines expressing HIV-1 subtype-C mosaic Gag

Author: Jongwe, Tsungai Ivai Date: 2015 Of the 35 million people living with HIV-1 globally, approximately 71.4% are in the resource-limited sub-Saharan Africa. The immense sequence diversity of HIV-1, even within subtypes, makes it challenging to develop effective vaccines that ... Read more
Construction, stability and immunogenicity of recombinant BCG expressing HIV-1 subtype C gag under the control of MtrA promoter, with or without the leader sequences

Author: Lebeko, Maribanyana R Date: 2011 This study aimed to compare recombinant mycobacteria expressing HIV-1 gag under the control of different promoters and leader sequences. This was done to determine whether the genetic stability of the recombinant mycobacteria could be improved ... Read more
Detection of natural infection with Mycobacterium intracellulare in healthy wild-caught Chacma baboons (Papio ursinus) by ESAT-6 and CFP-10 IFN-gamma ELISPOT tests following a tuberculosis outbreak

Author: Chege, Gerald ; Warren, Robin ; van Pittius, Nico ; Burgers, Wendy ; Wilkinson, Robert ; Shephard, Enid ; Williamson, Anna-Lise Date: 2008 BACKGROUND:Both tuberculous and non-tuberculous mycobacteria can cause infection in nonhuman primates (NHP), indicating the existence of potential zoonotic transmission between these animals and visitors to zoos or animal handlers in primate ... Read more c b
Determinants of sexual activity and its relation to cervical cancer risk among South African Women

Author: Cooper, Diane ; Hoffman, Margaret ; Carrara, Henri ; Rosenberg, Lynn ; Kelly, Judy ; Stander, Ilse ; Denny, Lynnette ; Williamson, Anna-Lise ; Shapiro, Samuel Date: 2007 BACKGROUND:Invasive cervical cancer is the commonest cause of cancer morbidity and mortality in South African women. This study provides information on adult women's sexual activity and cervical cancer risk in South Africa. METHODS: The data ... Read more c b

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