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Browsing by Author "Wilkinson, Katalin A"

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Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV-tuberculosis immune reconstitution inflammatory syndrome

Author: Skolimowska, Keira H ; Rangaka, Molebogeng X ; Meintjes, Graeme ; Pepper, Dominique J ; Seldon, Ronnett ; Matthews, Kerryn ; Wilkinson, Robert J ; Wilkinson, Katalin A Date: 2012 We have described a clinical relationship between HIV-Tuberculosis Immune Reconstitution Inflammatory Syndrome (TB-IRIS) and anti-tubercular drug resistance. Here we studied the immune response of TB-IRIS patients from whom a drug-resistant ... Read more c b
Conserved immune recognition hierarchy of mycobacterial PE/PPE proteins during infection in natural hosts

Author: Vordermeier, H Martin ; Hewinson, R Glyn ; Wilkinson, Robert J ; Wilkinson, Katalin A ; Gideon, Hannah P ; Young, Douglas B ; Sampson, Samantha L Date: 2012 The Mycobacterium tuberculosis genome contains two large gene families encoding proteins of unknown function, characterized by conserved N-terminal proline and glutamate (PE and PPE) motifs. The presence of a large number of PE/PPE proteins ... Read more c b
Detectable changes in the blood transcriptome are present after two weeks of antituberculosis therapy

Author: Bloom, Chloe I ; Graham, Christine M ; Berry, Matthew P R ; Wilkinson, Katalin A ; Oni, Tolu ; Rozakeas, Fotini ; Xu, Zhaohui ; Rossello-Urgell, Jose ; Chaussabel, Damien ; Banchereau, Jacques Date: 2012 Rationale: Globally there are approximately 9 million new active tuberculosis cases and 1.4 million deaths annually . Effective antituberculosis treatment monitoring is difficult as there are no existing biomarkers of poor adherence or ... Read more c b
Immune responses to the enduring hypoxic response antigen Rv0188 are preferentially detected in Mycobacterium bovis infected cattle with low pathology

Author: Jones, Gareth J ; Pirson, Chris ; Gideon, Hannah P ; Wilkinson, Katalin A ; Sherman, David R ; Wilkinson, Robert J ; Hewinson, R Glyn ; Vordermeier, H Martin Date: 2011 The DosR regulon and the Enduring Hypoxic Response (EHR) define a group of M. tuberculosis genes that are specifically induced in bacilli exposed in vitro to conditions thought to mimic the environment encountered by Mycobacteria during latent ... Read more c b
Immunological markers of protective immune reconstitution in HIV infected persons sensitised by Mycobacterium tuberculosis

Author: Jhilmeet, Nishtha Date: 2018 Tuberculosis (TB) is the leading cause of death from a single infectious agent worldwide and HIV-1 co-infection is the leading cause of susceptibility to tuberculosis. Sub-Saharan Africa has a high incidence of TB-HIV-1 coinfection and the ... Read more
Impairment of IFN-gamma response to synthetic peptides of mycobacterium tuberculosis in a 7-day whole blood assay

Author: Gideon, Hannah Priyadarshini ; Hamilton, Melissa Shea ; Wood, Kathryn ; Pepper, Dominique ; Oni, Tolu ; Seldon, Ronnett ; Banwell, Claire ; Langford, Paul R ; Wilkinson, Robert J ; Wilkinson, Katalin A Date: 2013 Studies on Mycobacterium tuberculosis (MTB) antigens are of interest in order to improve vaccine efficacy and to define biomarkers for diagnosis and treatment monitoring. The methodologies used for these investigations differ greatly between ... Read more c b
Modern lineages of Mycobacterium tuberculosis exhibit lineage-specific patterns of growth and cytokine induction in human monocyte-derived macrophages

Author: Sarkar, Rajesh ; Lenders, Laura ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Nicol, Mark P Date: 2012 BACKGROUND: Strains of Mycobacterium tuberculosis vary in virulence. Strains that have caused outbreaks in the United States and United Kingdom have been shown to subvert the innate immune response as a potential immune evasion mechanism. ... Read more c b
Prevalence, hemodynamics, and cytokine profile of effusive-constrictive pericarditis in patients with tuberculous pericardial effusion

Author: Ntsekhe, Mpiko ; Matthews, Kerryn ; Syed, Faisal F ; Deffur, Armin ; Badri, Motasim ; Commerford, Patrick J ; Gersh, Bernard J ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Mayosi, Bongani M Date: 2013 BACKGROUND: Effusive constrictive pericarditis (ECP) is visceral constriction in conjunction with compressive pericardial effusion. The prevalence of proven tuberculous ECP is unknown. Whilst ECP is distinguished from effusive disease on ... Read more c b
QuantiFERON conversion following tuberculin administration is common in HIV infection and relates to baseline response

Author: Esmail, Hanif ; Thienemann, Friedrich ; Oni, Tolu ; Goliath, Rene ; Wilkinson, Katalin A ; Wilkinson, Robert J Date: 07 Oct 2016 Background: HIV-1 infection impairs tuberculosis (TB) specific immune responses affecting the diagnosis of latent TB. We aimed to (1) determine the proportion of HIV-1-infected adults with a negative QuantiFERON®-TB Gold in-tube (QFT-GIT) and ... Read more c b
A Recent HIV Diagnosis Is Associated with Non-Completion of Isoniazid Preventive Therapy in an HIV-Infected Cohort in Cape Town

Author: Oni, Tolu ; Tsekela, Relebohile ; Kwaza, Bekekile ; Manjezi, Lulama ; Bangani, Nonzwakazi ; Wilkinson, Katalin A ; Coetzee, David ; Wilkinson, Robert J Date: 2012 Introduction: Despite high rates of successful treatment TB incidence in South Africa remains high, suggesting ongoing transmission and a large reservoir of latently infected persons. Isoniazid preventive therapy (IPT) is recommended as ... Read more c b
Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa

Author: Oni, Tolu ; Gideon, Hannah P ; Bangani, Nonzwakazi ; Tsekela, Relebohile ; Seldon, Ronnett ; Wood, Kathryn ; Wilkinson, Katalin A ; Goliath, Rene T ; Ottenhoff, Tom H M ; Wilkinson, Robert J Date: 2012 BACKGROUND: The increased susceptibility to latent tuberculosis infection (LTBI) of HIV-1-infected persons represents a challenge in TB epidemic control. However few studies have evaluated LTBI predictors in a generalized HIV/TB epidemic ... Read more c b
Transcriptional Blood Signatures Distinguish Pulmonary Tuberculosis, Pulmonary Sarcoidosis, Pneumonias and Lung Cancers

Author: Bloom, Chloe I ; Graham, Christine M ; Berry, Matthew P R ; Rozakeas, Fotini ; Redford, Paul S ; Wang, Yuanyuan ; Xu, Zhaohui ; Wilkinson, Katalin A ; Wilkinson, Robert J ; Kendrick, Yvonne Date: 2013 Rationale: New approaches to define factors underlying the immunopathogenesis of pulmonary diseases including sarcoidosis and tuberculosis are needed to develop new treatments and biomarkers. Comparing the blood transcriptional response of ... Read more c b

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Browsing by Author "Wilkinson, Katalin A"

Browsing by Author "Wilkinson, Katalin A"

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