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Browsing by Author "Tukulula, Matshawandile"

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The application of the Multi-Component Reaction (MCR) strategy in the design and synthesis of new antiplasmodial and antimycobacterial agents

Author: Tukulula, Matshawandile Date: 2012 Malaria and tuberculosis are ancient diseases that continue to have a profound impact on mankind, 5 millennia after their first documentation. Malaria is endemic in more than 100 countries and about 50% of the world's population is at risk ... Read more
New Quinoline–Urea–Benzothiazole Hybrids as Promising Antitubercular Agents: Synthesis, In Vitro Antitubercular Activity, Cytotoxicity Studies, and In Silico ADME Profiling

Author: Moodley, Rashmika ; Mashaba, Chakes ; Rakodi, Goitsemodimo H ; Ncube, Nomagugu B ; Maphoru, Mabuatsela V ; Balogun, Mohammed O ; Jordan, Audrey ; Warner, Digby F ; Khan, Rene ; Tukulula, Matshawandile Date: 05 May 2022 A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized successfully via a three-step synthetic sequence involving an amidation coupling reaction as a critical step. The structures of the synthesized compounds were ... Read more c b
Synthesis and In Vitro Antiprotozoan Evaluation of 4-/8-Aminoquinoline-based Lactams and Tetrazoles

Author: Tukulula, Matshawandile ; Louw, Stefan ; Njoroge, Mathew ; Chibale, Kelly Date: 15 Dec 2020 A second generation of 4-aminoquinoline- and 8-aminoquinoline-based tetrazoles and lactams were synthesized via the Staudinger and Ugi multicomponent reactions. These compounds were subsequently evaluated in vitro for their potential ... Read more c b

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Browsing by Author "Tukulula, Matshawandile"

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