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Browsing by Author "Tiffin, Nicki"

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Blood pressure gradients and cardiovascular risk factors in urban and rural populations in Abia State South Eastern Nigeria using the WHO STEPwise approach

Author: Okpechi, Ikechi Gareth ; Chukwuonye, Innocent Ijezie ; Tiffin, Nicki ; Madukwe, Okechukwu Ojoemelam ; Onyeonoro, Ugochukwu Uchenna ; Umeizudike, Theophilus Ifeanyichukwu ; Ogah, Okechukwu Samuel Date: 2013 BACKGROUND: Developing countries of sub-Saharan Africa (SSA) face a double burden of non-communicable diseases (NCDs) and communicable diseases. As high blood pressure (BP) is a common global cardiovascular (CV) disorder associated with high ... Read more c b
C-reactive protein and procalcitonin to discriminate between tuberculosis, Pneumocystis jirovecii pneumonia, and bacterial pneumonia in HIV-infected inpatients meeting WHO criteria for seriously ill: a prospective cohort study

Author: Mendelson, Fiona ; Griesel, Rulan ; Tiffin, Nicki ; Rangaka, Molebogeng ; Boulle, Andrew ; Mendelson, Marc ; Maartens, Gary Date: 14 Aug 2018 Background Tuberculosis, bacterial community-acquired pneumonia (CAP), and Pneumocystis jirovecii pneumonia (PJP) are the three commonest causes of hospitalisation in HIV-infected adults. Prompt diagnosis and treatment ... Read more
Computational analysis of candidate disease genes and variants for salt-sensitive hypertension in indigenous Southern Africans

Author: Tiffin, Nicki ; Meintjes, Ayton ; Ramesar, Rajkumar ; Bajic, Vladimir B. ; Rayner, Brian Date: 2010 Multiple factors underlie susceptibility to essential hypertension, including a significant genetic and ethnic component, and environmental effects. Blood pressure response of hypertensive individuals to salt is heterogeneous, but salt ... Read more c b
Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome

Author: Lombard, Zane ; Tiffin, Nicki ; Hofmann, Oliver ; Bajic, Vladimir ; Hide, Winston ; Ramsay, Michele Date: 2007 BACKGROUND:Fetal alcohol syndrome (FAS) is a serious global health problem and is observed at high frequencies in certain South African communities. Although in utero alcohol exposure is the primary trigger, there is evidence for genetic- and ... Read more c b
The development of computational biology in South Africa: successes achieved and lessons learnt

Author: Mulder, Nicola J ; Christoffels, Alan ; De Oliveira, Tulio ; Gamieldien, Junaid ; Hazelhurst, Scott ; Joubert, Fourie ; Kumuthini, Judit ; Pillay, Ché S ; Snoep, Jacky L ; Bishop, Özlem Tastan ; Tiffin, Nicki Date: 2016 Bioinformatics is now a critical skill in many research and commercial environments as biological data are increasing in both size and complexity. South African researchers recognized this need in the mid-1990s and responded by working with ... Read more c b
A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus

Author: Tiffin, Nicki ; Adeyemo, Adebowale ; Okpechi, Ikechi Date: 2013 Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease with variable clinical presentation frequently affecting the skin, joints, haemopoietic system, kidneys, lungs and central nervous system. It can be life threatening ... Read more c b
Genetic variation at selected SNPs in the leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa

Author: Okpechi, Ikechi G ; Rayner, Brian L ; van der Merwe, Lize ; Mayosi, Bongani M ; Adeyemo, Adebowale ; Tiffin, Nicki ; Ramesar, Rajkumar Date: 2010 BACKGROUND: Chronic kidney disease (CKD) is a significant public health problem that leads to end-stage renal disease (ESRD) with as many as 2 million people predicted to need therapy worldwide by 2010. Obesity is a risk factor for CKD and ... Read more c b
Incident tuberculosis disease in patients receiving biologic therapies in the Western Cape, South Africa from 2007 to 2018

Author: du Toit, Tessa ; Esterhuizen, Tonya M ; Tiffin, Nicki ; Abulfathi, Ahmed A ; Reuter, Helmuth ; Decloedt, Eric H Date: 30 Nov 2020 Abstract Background South Africa has one of the highest tuberculosis incidence rates. Biologic disease-modifying anti-rheumatic drugs are associated with an increased risk of tuberculosis. The objective of this study was to describe the ... Read more
Potential risks and solutions for sharing genome summary data from African populations

Author: Tiffin, Nicki Date: 04 Nov 2019 Abstract Genome data from African population can substantially assist the global effort to identify aetiological genetic variants, but open access to aggregated genomic data from these populations poses some significant risks ... Read more
The effects of add-on corticosteroids on renal outcomes in patients with biopsy proven HIV associated nephropathy: a single centre study from South Africa

Author: Wearne, Nicola ; Swanepoel, Charles R ; Duffield, Maureen S ; Davidson, Bianca J ; Manning, Kathryn ; Tiffin, Nicki ; Boulle, Andrew ; Rayner, Brian L ; Naidu, Priyanka ; Okpechi, Ikechi G Date: 06 Feb 2019 Background The aim of this study was to assess, the efficacy and safety of add-on corticosteroids to antiretroviral therapy [ART] in patients with biopsy proven HIV associated nephropathy. ... Read more

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