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Browsing by Author "Smith, Peter J"

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Antimalarial activity and cytotoxicity of some South African medicinal plants and their active constituents

Author: Sekhoacha, Mamello Date: 2008 Includes bibliographical references (leaves 150-187). Read more
The antimalarial activity of Dicoma anomala and the chloroquine resistance reversing effects of Sclerocarya birrea on Plasmodium falciparum in vitro

Author: Matsabisa, Motlalepula Gilbert Date: 2001 Two plants, Dicoma anomala [Sond.]; a member of the Asteraceae and Sclerocarya birrea [(A. Rich) Hoechst. subspecies caffra (Sond.) Kokwaro], a member of the Anarcadiaceae families, are used widely in Africa for a variety of traditional ... Read more
Antimycobacterial activity of the red algae gelidium pristoides, plocamium corallorhiza and polysiphonia virgata

Author: Saravanakumar, Denise Date: 2006 In 1993, the World Health Organisation declared tuberculosis a global health emergency. Currently, efforts are underway to improve the way the disease is managed and to find more effective treatments that would combat the problem of long ... Read more
The antiplasmodial, toxicity and pharmacokinetic properties of synthetic derivatives of the natural product Curcumin

Author: Okalebo, Faith Apolot Date: 2008 Includes bibliographical references. Read more
Association of lopinavir concentrations with plasma lipid or glucose concentrations in HIV-infected South Africans: a cross sectional study

Author: Sinxadi, Phumla Z ; McIlleron, Helen M ; Dave, Joel A ; Smith, Peter J ; Levitt, Naomi S ; Maartens, Gary Date: 26 Oct 2012 Abstract Background Dyslipidaemia and dysglycaemia have been associated with exposure to ritonavir-boosted protease inhibitors. Lopinavir/ritonavir, the most commonly used protease inhibitor ... Read more c b
Characterisation of the ATPase activity and study of the chloroquine accumulation properties of purified Plasmodium falciparum plasma membranes

Author: Elandalloussi, Laurence M Date: 2000 Bibliography: p. 130-155. Read more
Chemical modification and pharmacological evaluation of the antimalarial natural product totarol

Author: Tacon, Claire Date: 2004 Includes bibliographical references. Read more
Chloroquine accumulation in Plasmodium falciparum isolated digestive vacuoles

Author: Saliba, Kevin John Date: 1997 Due to the development of drug-resistance by Plasmodium falciparum, the utilisation of chloroquine, a cheap and effective antimalarial has become limited. The mechanism of chloroquine-resistance is, at best, unresolved. This thesis describes ... Read more
Expression of the P-glycoprotein Homologue1 on food vacuoles isolated from Chloroquine-sensitive and resistant Plasmodium falciparum strains

Author: Lindt, Meinrad Date: 1999 Worldwide occurrence of chloroquine resistance is an expanding problem in prophylaxis and treatment of malaria. Similarities between the drug resistance phenotype in certain cancers and in malaria suggest that homologue multidrug resistance ... Read more
In vitro efficacy tests against Mycobacterium species of South African traditional medicinal plants

Author: Ntutela, Siyabulela Calvin Sibusiso Date: 2002 Tuberculosis is the leading cause of death due to a single organism; with a mortality of more than 3million people each year, worldwide. The emergence of multi-drug resistance and HIV/AIDS are the major causes of this problem. New therapeutic ... Read more
In vivo effects of South African traditional medicines against Mycobacterium tuberculosis in experimental mice

Author: Bapela, Nchinya Benedict Date: 2001 Although it is more than 100 years since Robert Koch discovered the tubercle bacillus, and more than 40 years since effective chemotherapy became available, the incidence of tuberculosis is increasing in much of the developing world and has ... Read more
Investigation of the phytochemistry and biological activity of isoquinoline alkaloids isolated from the South African medicinal plants, cyrtanthus sanguineus (Lindl.) walp. and cyrtanthus obliquus (L.f.)ait

Author: Brine, Natalie Dawn Date: 2001 The term "traditional medicine" refers to the ways of protecting and restoring health that existed before the arrival of modern medicine. These approaches to health belong to the traditions of each country and have been handed down from ... Read more
Isolation and characterisation of antiplasmodial compounds from Xerophyta species and the bioavailability, metabolic and efficacy evaluation of 9-0-acetylhydnocarpin in a mouse model

Author: Wiesner, Lubbe Date: 2008 Includes abstract. Includes bibliographical references (leaves 237-265). Read more
Isolation and characterization of antiplasmodial compounds from Siphonochilus aethiopicus and Aloe ferox and bioavailability of a novel furanoterpenoid

Author: Lategan, Carmen Date: 2008 Includes abstract. Includes bibliographical references (leaves 138-162). Read more
The isolation of anti-mycobacterial compounds from South African medicinal plants

Author: Madikane, Eliya Vukani Date: 2005 Includes bibliographical references. Read more
A post-mortem toxicological investigation: Understanding the role of drugs of abuse in violent fatalities in Cape Town, South Africa

Author: Auckloo, Marie Belle Kathrina Mendoza Date: 2016 Violence and resulting injuries are critical health burdens worldwide, accounting for the death of millions of individuals annually. The literature reports an association between drug use and violence, providing data indicating that the use ... Read more
The role of the pharmacokinetics, host folate levels and parasite mutations in the in vivo efficacy of pyrimethamine-sulfadoxine against Plasmodium falciparum

Author: Dzinjalamala, Fraction Kunseu Date: 2003 Includes bibliographical references. Read more
Studies on in vitro antiplasmodial activity of cleome rutidosperma

Author: Bose, Anindya ; Lategan, Carmen Abriette ; Smith, Peter J ; Gupta, Jayanta Kumar Date: 2010 Malaria is a protozoal disease transmitted by the Anopheles mosquito, caused by minute parasitic protozoa of the genus Plasmodium, which infect human and insect hosts alternatively. It affects over 40% of the worldís population, with 120 ... Read more

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Browsing by Author "Smith, Peter J"

Browsing by Author "Smith, Peter J"

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